Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 7/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496508 | 0.73 | FFAR2 (0.35) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL6505584 | 0.72 | DGAT1 (0.38) | NPC1RAB9AL3MBTL1KDM4EMAPT | |
| SCHEMBL6496601 | 0.72 | KMT2A (0.48) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL6503265 | 0.71 | HPGD (0.56) | NPC1RAB9AL3MBTL1KDM4EMAPT | |
| SCHEMBL21361932 | 0.70 | NPC1 (0.58) | NPC1RAB9AL3MBTL1KDM4EMAPT | |
| SCHEMBL21361937 | 0.69 | HPGD (0.70) | NPC1RAB9AL3MBTL1KDM4EMAPT | |
| SCHEMBL6498480 | 0.69 | CTSA (0.39) | NPC1RAB9AL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL22862244 | 0.68 | NPC1 (0.61) | NPC1RAB9AL3MBTL1KDM4EMAPT | |
| SCHEMBL17117202 | 0.68 | RAB9A (1.00) | NPC1RAB9AKDM4EMAPTHSD17B10 | |
| SCHEMBL21361939 | 0.67 | NPC1 (0.65) | NPC1RAB9AL3MBTL1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |