Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 5/20 | 0.35 |
| ▸ | HTR2C | P28335 | 5/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505584 | 0.82 | DGAT1 (0.38) | ALDH1A1SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL6496508 | 0.82 | FFAR2 (0.35) | CTSAALDH1A1SMN1; SMN2HTR2CNPC1 | |
| SCHEMBL6496054 | 0.73 | KDM4E (0.40) | ALDH1A1SMN1; SMN2CYP2C19NPC1RAB9A | |
| SCHEMBL6495786 | 0.73 | NPC1 (0.38) | ALDH1A1SMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL7684255 | 0.73 | SHMT1 (0.40) | CTSAALDH1A1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL6498475 | 0.73 | PPARA (0.46) | ALDH1A1LMNAMAPT | |
| SCHEMBL6505070 | 0.72 | TRPV1 (0.35) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL6503799 | 0.71 | EGLN2 (0.35) | ALDH1A1SMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL6502680 | 0.70 | CDC7 (0.41) | SMN1; SMN2NPC1RAB9ATP53LMNA | |
| SCHEMBL6503268 | 0.69 | NPC1 (0.60) | ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |