Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.54 |
| ▸ | HTR2A | P28223 | 6/20 | 0.54 |
| ▸ | HTR2C | P28335 | 6/20 | 0.54 |
| ▸ | DRD2 | P14416 | 6/20 | 0.54 |
| ▸ | DRD3 | P35462 | 5/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6501509 | 0.91 | HTR6 (0.46) | HTR6HTR2AHTR2CDRD2DRD3 | |
| SCHEMBL6508620 | 0.90 | MAPT (0.49) | HTR6HTR2AHTR2CDRD2DRD3 | |
| SCHEMBL6500880 | 0.90 | LMNA (0.51) | HTR6DRD2DRD3PDE4BLMNA | |
| SCHEMBL6502583 | 0.90 | LMNA (0.48) | HTR6HTR2AHTR2CDRD2DRD3 | |
| SCHEMBL6510748 | 0.90 | HTR6 (0.46) | HTR6HTR2AHTR2CDRD2DRD3 | |
| SCHEMBL6509242 | 0.89 | MAOB (0.54) | HTR6HTR2AHTR2CLMNAMAPT | |
| SCHEMBL6506073 | 0.88 | LMNA (0.44) | HTR6HTR2AHTR2CDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL6504357 | 0.88 | MAOB (0.53) | HTR6HTR2AHTR2CLMNAMAPT | |
| SCHEMBL6507562 | 0.86 | MAPT (0.57) | HTR6DRD2LMNAMAPTHTR1A | |
| SCHEMBL6508601 | 0.86 | TNF (0.48) | LMNAMAPTTSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005014578-A1 | PHENYLSULFONYL COMPOUNDS AS ANTIPSYCHOTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2005-02-17 | — | — | WO | claimed |
| WO-2005014578-A1 | PHENYLSULFONYL COMPOUNDS AS ANTIPSYCHOTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2005-02-17 | — | — | WO | disclosed |