Sugi Predict

Sugi Predict / Compounds / SCHEMBL6514486

SCHEMBL6514486

SCHEMBL6514486

COc1cc2cc[nH]c2c(OC)c1OC

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 5/20 0.47
▸ KDM4E B2RXH2 2/20 0.46
▸ ALDH1A1 P00352 2/20 0.46
▸ HPGD P15428 2/20 0.46
▸ LMNA P02545 1/20 0.46
▸ TUBB4A P04350 1/20 0.44
▸ TUBB P07437 1/20 0.44
▸ TUBA3C P0DPH7 1/20 0.44
▸ TUBA1B P68363 1/20 0.44
▸ TUBA4A P68366 1/20 0.44
▸ TUBB4B P68371 1/20 0.44
▸ TUBB3 Q13509 1/20 0.44
▸ TUBB2A Q13885 1/20 0.44
▸ TUBB8 Q3ZCM7 1/20 0.44
▸ TUBA3E Q6PEY2 1/20 0.44
▸ TUBA1A Q71U36 1/20 0.44
▸ TUBA1C Q9BQE3 1/20 0.44
▸ TUBB6 Q9BUF5 1/20 0.44
▸ TUBB2B Q9BVA1 1/20 0.44
▸ TUBB1 Q9H4B7 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31375352 0.85 BRD4 (0.45) BRD4KDM4EALDH1A1HPGDLMNA
SCHEMBL31375348 0.84 BRD4 (0.44) BRD4KDM4EALDH1A1HPGDLMNA
SCHEMBL9315325 0.84 TUBB4A (0.41) BRD4KDM4EALDH1A1HPGDLMNA
SCHEMBL18639763 0.79 MEN1 (0.38) BRD4ALDH1A1TUBB4ATUBBTUBA3C
SCHEMBL7835424 0.78 BRD4 (0.45) BRD4KDM4EALDH1A1HPGDTUBB4A
SCHEMBL30261030 0.78 BRD4 (0.45) BRD4KDM4EALDH1A1HPGDTUBB4A
SCHEMBL34465699 0.76 TNF (0.43) BRD4TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL7291038 0.75 CYP19A1 (0.50) BRD4KDM4EALDH1A1HPGDLMNA
SCHEMBL8578238 0.74 ACHE (0.45) BRD4ALDH1A1TUBB4ATUBBTUBA3C
SCHEMBL1748919 0.74 MEN1 (0.48) KDM4EALDH1A1HPGDCA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250381202-A1 PRODRUG KIT FOR MULTI-PRONGED CHEMOTHERAPY ZOUNEK ALEX (DE) 2025-12-18 — — US disclosed
EP-4598586-A1 DRUG LINKERS AND ANTIBODY CONJUGATES THEREOF Ambrx, Inc. (US) 2025-08-13 — — EP disclosed
CN-113439084-B Sesqui-carcinomycin analogue 奥克兰联合服务有限公司 2025-02-25 — — CN disclosed
WO-2024077277-A1 DRUG LINKERS AND ANTIBODY CONJUGATES THEREOF AMBRX, INC. (US) 2024-04-11 — — WO disclosed
US-20220098215-A1 DUOCARMYCIN ANALOGUES AUCKLAND UNISERVICES LIMITED (NZ) 2022-03-31 — — US disclosed
EP-3917933-A1 DUOCARMYCIN ANALOGUES Auckland Uniservices Limited (NZ) 2021-12-08 — — EP disclosed
CN-113439084-A Duocarmycin analogs 奥克兰联合服务有限公司 2021-09-24 — — CN disclosed
WO-2020157662-A1 DUOCARMYCIN ANALOGUES AUCKLAND UNISERVICES LIMITED (NZ) 2020-08-06 — — WO disclosed
US-10287291-B2 Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use BRISTOL-MYERS SQUIBB COMPANY (US) 2019-05-14 — — US disclosed
US-10266547-B2 Thieno[2,3-e]indole derivatives as new antitumor agents NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2019-04-23 — — US disclosed
CN-102827061-A 5,6,7- trimethoxy indole derivative, preparation method and use thereof UNIV LANGZHOU 2012-12-19 — — CN disclosed
CN-102827061-A 5,6,7- trimethoxy indole derivative, preparation method and use thereof UNIV LANGZHOU 2012-12-19 — — CN disclosed
CN-102827061-A 5,6,7- trimethoxy indole derivative, preparation method and use thereof UNIV LANGZHOU 2012-12-19 — — CN disclosed
US-20050026987-A1 CBI analogues of the duocarmycins and CC-1065 THE SCRIPPS RESEARCH INSTITUTE (US) 2005-02-03 — — US disclosed
WO-2004101767-A2 CBI ANALOGUES OF THE DUOCARMYCINS AND CC-1065 THE SCRIPPS RESEARCH INSTITUTE (US) 2004-11-25 — — WO disclosed
US-6060608-A ANTITUMOR AGENTS THE SCRIPPS RESEARCH INSTITUTE (US) 2000-05-09 — — US disclosed
EP-0934269-A4 ANALOGS OF CC-1065 AND THE DUOCARMYCINS SCRIPPS RESEARCH INST (US) 2000-01-12 — — EP disclosed
EP-0934269-A1 ANALOGS OF CC-1065 AND THE DUOCARMYCINS The Scripps Research Institute (US) 1999-08-11 — — EP disclosed
WO-1997045411-A9 ANALOGS OF CC-1065 AND THE DUOCARMYCINS — 1998-04-09 — — WO disclosed
WO-1997045411-A1 ANALOGS OF CC-1065 AND THE DUOCARMYCINS THE SCRIPPS RESEARCH INSTITUTE (US) 1997-12-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250381202-A1 PRODRUG KIT FOR MULTI-PRONGED CHEMOTHERAPY KIT, CTSL, PAICS BRD4 3312/4885KDM4E 2995/4885ALDH1A1 1779/4885
US-20050026987-A1 CBI analogues of the duocarmycins and CC-1065 CCNI, SP1, DCK BRD4 211/4885KDM4E 1508/4885ALDH1A1 4597/4885
US-20220098215-A1 DUOCARMYCIN ANALOGUES TOP2A, TOP2B, MUS81 BRD4 805/4885KDM4E 406/4885ALDH1A1 2426/4885
US-10266547-B2 Thieno[2,3-e]indole derivatives as new antitumor agents INMT, TOP2A, TOP1 BRD4 228/4885KDM4E 371/4885ALDH1A1 1221/4885
US-10287291-B2 Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use CD22, GDI2, GDI1 BRD4 1729/4885KDM4E 3689/4885ALDH1A1 340/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.