Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGM | P11217 | 3/20 | 0.65 |
| ▸ | TK2 | O00142 | 2/20 | 0.60 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.56 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.55 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.55 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.55 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.55 |
| ▸ | P2RY2 | P41231 | 4/20 | 0.53 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.51 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.51 |
| ▸ | NT5E | P21589 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1138786 | 0.95 | PYGM (0.70) | PYGMTK2DNPH1SLC28A1SLC28A2 | |
| SCHEMBL1138789 | 0.95 | PYGM (0.70) | PYGMTK2DNPH1SLC28A1SLC28A2 | |
| SCHEMBL6671812 | 0.95 | PYGM (0.70) | PYGMTK2DNPH1SLC28A1SLC28A2 | |
| Phosphoric Acid SCHEMBL3515238 | 0.85 | PYGM (0.88) | PYGMTK2DNPH1SLC28A1SLC28A2 | |
| Phosphoric Acid SCHEMBL14778308 | 0.85 | PYGM (0.65) | PYGMTK2DNPH1P2RY2 | |
| Phosphoric Acid SCHEMBL4949865 | 0.85 | PYGM (0.88) | PYGMTK2DNPH1SLC28A1SLC28A2 | |
| Phosphoric Acid SCHEMBL2883627 | 0.85 | PYGM (0.65) | PYGMTK2DNPH1P2RY2 | |
| 5-Fluorouridine SCHEMBL148674 | 0.85 | P2RY6 (0.68) | PYGMTK2DNPH1SLC28A1SLC28A2 | |
| 5-Fluorouridine SCHEMBL668873 | 0.85 | P2RY6 (0.68) | PYGMTK2DNPH1SLC28A1SLC28A2 | |
| Phosphoric Acid SCHEMBL9804833 | 0.85 | PYGM (0.88) | PYGMTK2DNPH1SLC28A1SLC28A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050003371-A1 | Modified nucleotides and methods of labeling nucleic acids | STRATAGENE | 2005-01-06 | — | — | US | disclosed |
| WO-2004037989-A2 | MODIFIED NUCLEOTIDES AND METHODS OF LABELING NUCLEIC ACIDS | STRATAGENE (US) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050003371-A1 | Modified nucleotides and methods of labeling nucleic acids | RNGTT, NT5C3B, NT5E | PYGM 1414/4885TK2 108/4885DNPH1 251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.