Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 11/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.41 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6526565 | 0.86 | KCNA5 (0.40) | GLSCYP2D6OPRK1NPFFR1NPFFR2 | |
| SCHEMBL13293669 | 0.77 | ROCK2 (0.55) | GLSROCK2CYP2D6NPFFR1NPFFR2 | |
| SCHEMBL28211519 | 0.74 | GLS (0.62) | GLSBRD4 | |
| SCHEMBL2787151 | 0.74 | GLS (0.58) | GLSBRD4NAMPT | |
| SCHEMBL5843322 | 0.73 | OPRK1 (0.77) | CYP2D6OPRK1 | |
| SCHEMBL185365 | 0.72 | ATM (0.55) | GLSBRD4NAMPT | |
| SCHEMBL14367982 | 0.72 | PRMT6 (0.56) | GLSROCK2BRD4NAMPT | |
| SCHEMBL14986954 | 0.71 | GLS (0.57) | GLSBRD4NAMPT | |
| SCHEMBL8786913 | 0.71 | GLS (0.57) | GLSBRD4NAMPT | |
| SCHEMBL2066840 | 0.71 | SIGMAR1 (0.46) | CYP2D6NPFFR1NPFFR2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005004796-A2 | SULFONYLAMINO PHENYLACETAMIDE DERIVATIVES AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2005-01-20 | — | — | WO | disclosed |