Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6516746 | 0.72 | POLB (0.39) | P2RX7KDM4EALDH1A1KIF11MEN1 | |
| SCHEMBL5821050 | 0.68 | KIF11 (0.42) | KDM4EALDH1A1HPGDKIF11LMNA | |
| SCHEMBL5766155 | 0.66 | P2RX7 (0.40) | P2RX7KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL5724300 | 0.64 | KIF11 (0.55) | KDM4EKIF11MEN1KMT2ATDP1 | |
| SCHEMBL5532768 | 0.64 | KIF11 (0.47) | KDM4EKIF11MEN1KMT2ATDP1 | |
| SCHEMBL4039832 | 0.63 | KIF11 (0.48) | P2RX7KDM4EKIF11MAPT | |
| SCHEMBL4715775 | 0.60 | KIF11 (0.51) | KDM4ESMN1; SMN2ALDH1A1KIF11MEN1 | |
| SCHEMBL5765941 | 0.59 | PDE4A (0.51) | MAPTPDE1C | |
| SCHEMBL16133641 | 0.59 | MAPT (0.46) | KDM4ESMN1; SMN2TP53LMNAMAPT | |
| SCHEMBL29213309 | 0.58 | GGT1 (0.55) | ALDH1A1MEN1KMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234080-A1 | Mitotic kinesin inhibitors | COLEMAN PAUL J | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234080-A1 | Mitotic kinesin inhibitors | KIF5B, KIF2C, KIFC1 | P2RX7 4769/4885EGLN1 3381/4885CHRM4 4663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.