Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 10/20 | 0.55 |
| ▸ | HTR2C | P28335 | 7/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2414192 | 0.84 | DRD4 (0.54) | DRD4HTR2CDRD2DRD3MAPT | |
| SCHEMBL9048864 | 0.82 | DRD4 (0.52) | DRD4HTR2CDRD2DRD3MAPT | |
| SCHEMBL15180418 | 0.82 | DRD4 (0.52) | DRD4HTR2CDRD2DRD3MAPT | |
| SCHEMBL6533713 | 0.82 | NOTUM (0.51) | DRD4HTR2CDRD2DRD3MAPT | |
| SCHEMBL28980400 | 0.82 | MEN1 (0.41) | DRD4HTR2CDRD2DRD3MAPT | |
| SCHEMBL2412911 | 0.81 | GAA (0.58) | DRD4HTR2CDRD2DRD3MAPT | |
| SCHEMBL6532804 | 0.81 | NPBWR1 (0.43) | DRD4HTR2CDRD2DRD3NOTUM | |
| SCHEMBL6530604 | 0.81 | LMNA (0.41) | DRD4HTR2CDRD2DRD3MAPT | |
| SCHEMBL1930732 | 0.81 | GABRA1 (0.43) | DRD4HTR2CDRD2DRD3MAPT | |
| SCHEMBL28629989 | 0.80 | DRD4 (0.51) | DRD4HTR2CDRD2DRD3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689644-B | Pyridazinone compound and application thereof | 沈阳中化农药化工研发有限公司 | 2021-07-30 | — | — | CN | disclosed |
| CN-107964007-B | Pyridazinone compound and application thereof | 沈阳中化农药化工研发有限公司 | 2021-02-12 | — | — | CN | disclosed |
| EP-3081565-B9 | PYRAZOLYL PYRIMIDINAMINE COMPOUND AND APPLICATION THEREOF | SHENYANG SINOCHEM AGROCHEMICALS R & D CO LTD (CN) | 2020-08-12 | — | — | EP | disclosed |
| CN-109689644-A | Pyridazinone compound and its application | 沈阳中化农药化工研发有限公司 | 2019-04-26 | — | — | CN | disclosed |
| US-9682962-B2 | Pyrazolyl pyrimidinamine compound and application thereof | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2017-06-20 | — | — | US | disclosed |
| US-9682962-B2 | Pyrazolyl pyrimidinamine compound and application thereof | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2017-06-20 | — | — | US | disclosed |
| US-9682962-B2 | Pyrazolyl pyrimidinamine compound and application thereof | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2017-06-20 | — | — | US | disclosed |
| US-20160332991-A1 | PYRAZOLYL PYRIMIDINAMINE COMPOUND AND APPLICATION THEREOF | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2016-11-17 | — | — | US | disclosed |
| US-20160332991-A1 | PYRAZOLYL PYRIMIDINAMINE COMPOUND AND APPLICATION THEREOF | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2016-11-17 | — | — | US | disclosed |
| US-20160332991-A1 | PYRAZOLYL PYRIMIDINAMINE COMPOUND AND APPLICATION THEREOF | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2016-11-17 | — | — | US | disclosed |
| EP-3081565-A1 | PYRAZOLYL PYRIMIDINAMINE COMPOUND AND APPLICATION THEREOF | Shenyang Sinochem Agrochemicals R & D Co., Ltd. (CN) | 2016-10-19 | — | — | EP | disclosed |
| EP-3081565-A1 | PYRAZOLYL PYRIMIDINAMINE COMPOUND AND APPLICATION THEREOF | Shenyang Sinochem Agrochemicals R & D Co., Ltd. (CN) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015085935-A1 | PYRAZOLYL PYRIMIDINAMINE COMPOUND AND APPLICATION THEREOF | 中国中化股份有限公司 | 2015-06-18 | — | — | WO | disclosed |
| WO-2005040127-A1 | NOVEL COMPOUNDS AS AGONIST FOR PPAR GAMMA AND PPAR ALPHA, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | LG LIFE SCIENCES LTD. (KR) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160332991-A1 | PYRAZOLYL PYRIMIDINAMINE COMPOUND AND APPLICATION THEREOF | CTRC, APRT, MASTL | DRD4 3889/4885HTR2C 1930/4885DRD2 2885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.