Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 9/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6535210 | 0.89 | LMNA (0.52) | LMNAMAPTTP53CNR2PKM | |
| SCHEMBL7865941 | 0.84 | FFAR4 (0.52) | LMNAMAPTCNR2PKMHTR6 | |
| SCHEMBL4745384 | 0.76 | PKM (0.79) | LMNAMAPTTP53PKMFFAR4 | |
| SCHEMBL6534945 | 0.75 | FFAR4 (0.56) | LMNAMAPTTP53CNR2PKM | |
| SCHEMBL13241565 | 0.74 | PKM (0.63) | LMNAPKMFLT1FLT4KDR | |
| SCHEMBL24587258 | 0.73 | CCR2 (0.63) | CCR2 | |
| SCHEMBL6535042 | 0.70 | TRPV4 (0.55) | TP53HTR6 | |
| SCHEMBL28829848 | 0.70 | CCR2 (0.51) | LMNACCR2 | |
| SCHEMBL8145743 | 0.70 | PKM (0.62) | MAPTCNR2PKMHTR6FFAR4 | |
| SCHEMBL6534765 | 0.70 | HTR6 (0.65) | MAPTCNR2HTR6CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1011652-A4 | NOVEL DIARYLSULFONE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS | UNIV THE SCIENCES IN PHILADELP (US) | 2004-12-22 | — | — | EP | disclosed |
| US-6303630-B1 | TREATING HUMAN IMMUNODEFICIENCY VIRUS INFECTION BYADMINISTERING TO A HUMAN DIARYLSULFONE COMPOUND | UNIVERSITY OF THE SCIENCES IN PHILADELPHIA | 2001-10-16 | — | — | US | disclosed |
| EP-1011652-A1 | NOVEL DIARYLSULFONE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS | University of the Sciences in Philadelphia (US) | 2000-06-28 | — | — | EP | disclosed |
| US-6063790-A | TREATMENT OF AIDS | UNIVERSITY OF THE SCIENCES IN PHILADELPHIA (US) | 2000-05-16 | — | — | US | disclosed |
| WO-1999006037-A1 | NOVEL DIARYLSULFONE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS | UNIVERSITY OF THE SCIENCES IN PHILADELPHIA (US) | 1999-02-11 | — | — | WO | disclosed |