Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 6/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7718461 | 0.83 | NPC1 (0.45) | CTSBPPARGPDE4APDE4BPDE4C | |
| SCHEMBL6551633 | 0.77 | ALOX5 (0.35) | ALOX5ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8823589 | 0.69 | TUBB4A (0.50) | ALDH1A1NPC1RAB9ATSHRPARP1 | |
| SCHEMBL9222914 | 0.66 | LMNA (0.50) | ALDH1A1SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL6552154 | 0.66 | ALDH1A1 (0.35) | PPARGALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL8823569 | 0.65 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL6898521 | 0.64 | THRB (0.56) | ALDH1A1HPGDKMT2A | |
| SCHEMBL6919672 | 0.64 | PARP1 (0.46) | ALDH1A1PARP1HPGDKMT2AL3MBTL1 | |
| SCHEMBL7268595 | 0.63 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL9511701 | 0.62 | ALOX5 (0.45) | ALOX5ALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051402-B1 | METHOD FOR PRODUCING S-ALKYL(ARYL)-SUBSTITUTED IMIDAZOLE DERIVATIVES | AVENTIS PHARMA GMBH (DE) | 2004-12-08 | — | — | EP | disclosed |
| EP-1051402-A1 | METHOD FOR PRODUCING S-ALKYL(ARYL)-SUBSTITUTED IMIDAZOL DERIVATIVES | Aventis Pharma Deutschland GmbH (DE) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037620-A1 | METHOD FOR PRODUCING S-ALKYL(ARYL)-SUBSTITUTED IMIDAZOL DERIVATIVES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-29 | — | — | WO | disclosed |