Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | BRS3 | P32247 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6552425 | 0.85 | LTB4R (0.57) | KDM4EGAALTB4RHSD17B10ALDH1A1 | |
| SCHEMBL7044623 | 0.85 | NPC1 (0.43) | SRD5A2GAARAB9ALTB4RALDH1A1 | |
| SCHEMBL7044697 | 0.84 | RHEB (0.45) | KDM4ERAB9ALTB4RALDH1A1BRS3 | |
| SCHEMBL7044996 | 0.84 | TRPM8 (0.46) | KDM4EGAARAB9AHSD17B10ALDH1A1 | |
| SCHEMBL7042640 | 0.81 | SMN1; SMN2 (0.46) | RAB9AALDH1A1TP53MEN1LMNA | |
| SCHEMBL6553813 | 0.81 | MMP2 (0.48) | KDM4ERAB9ALTB4RALDH1A1MEN1 | |
| SCHEMBL7044700 | 0.80 | SMN1; SMN2 (0.52) | KDM4ERAB9AHSD17B10ALDH1A1RXFP1 | |
| SCHEMBL7044713 | 0.79 | RXFP1 (0.41) | KDM4EGAARAB9ARXFP1TP53 | |
| SCHEMBL15964617 | 0.76 | SRD5A2 (0.49) | PIN1SRD5A2KDM4EGAARAB9A | |
| SCHEMBL7044203 | 0.76 | SMN1; SMN2 (0.51) | RAB9AALDH1A1TP53MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482794-A1 | METHOD OF TREATMENT OR PREVENTION OF OBESITY | Merck & Co., Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003075660-A1 | METHOD OF TREATMENT OR PREVENTION OF OBESITY | MERCK & CO., INC. (US) | 2003-09-18 | — | — | WO | disclosed |
| WO-2003007887-A2 | SUBSTITUTED IMIDAZOLES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-01-30 | — | — | WO | disclosed |