Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.43 |
| ▸ | VNN1 | O95497 | 3/20 | 0.42 |
| ▸ | KLK1 | P06870 | 1/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.37 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.37 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7677085 | 0.84 | VNN1 (0.46) | GRM5VNN1 | |
| SCHEMBL6563625 | 0.83 | PRSS1 (0.43) | MRGPRX1PRSS1ALDH1A1HPGDRAB9A | |
| SCHEMBL6563729 | 0.81 | PPARG (0.41) | GRM5VNN1DHFR | |
| SCHEMBL7676492 | 0.79 | CCNA2 (0.41) | VNN1MRGPRX1PRSS1ALDH1A1RAB9A | |
| SCHEMBL7678092 | 0.78 | F2 (0.40) | KLK1KLK5MRGPRX1PRSS1ALDH1A1 | |
| SCHEMBL7669697 | 0.78 | MAPK13 (0.40) | PRSS1ALDH1A1HPGDRAB9AF2 | |
| SCHEMBL7673754 | 0.76 | NQO2 (0.41) | MRGPRX1PRSS1ALDH1A1HPGDF2 | |
| SCHEMBL6563277 | 0.75 | F2 (0.41) | KLK1KLK5MRGPRX1PRSS1F2 | |
| SCHEMBL7670696 | 0.75 | KMT2A (0.44) | KLK1KLK5MRGPRX1PRSS1RAB9A | |
| SCHEMBL6565262 | 0.74 | ALDH1A1 (0.45) | PRSS1ALDH1A1HPGDRAB9AF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |