Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 3/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.37 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.37 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6561921 | 0.91 | MAPK13 (0.45) | MAPK13MAPK12MAPK11MAPK14MAPK1 | |
| SCHEMBL7678092 | 0.89 | F2 (0.40) | MAPK13MAPK12MAPK11MAPK14PRSS1 | |
| SCHEMBL6565262 | 0.85 | ALDH1A1 (0.45) | PRSS1ALDH1A1HPGDRAB9AF2 | |
| SCHEMBL6563625 | 0.83 | PRSS1 (0.43) | MAPK13MAPK12MAPK11MAPK14PRSS1 | |
| SCHEMBL6561914 | 0.78 | GRM5 (0.43) | PRSS1ALDH1A1HPGDRAB9AF2 | |
| SCHEMBL7675043 | 0.77 | F7 (0.42) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6563277 | 0.77 | F2 (0.41) | MAPK13MAPK12MAPK11MAPK14PRSS1 | |
| SCHEMBL7673754 | 0.76 | NQO2 (0.41) | PRSS1ALDH1A1HPGDF2PRSS2 | |
| SCHEMBL6565690 | 0.74 | PLAU (0.54) | PRSS1RAB9AF2PRSS2PRSS3 | |
| SCHEMBL6565256 | 0.74 | AKR1C3 (0.44) | PRSS1ALDH1A1F2PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |
| EP-1140802-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM KG (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035859-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-06-22 | — | — | WO | disclosed |