Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1A1 | P14550 | 4/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.62 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 5/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.53 |
| ▸ | HTR1D | P28221 | 5/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6576335 | 0.82 | AKR1A1 (0.53) | AKR1A1AKR1B1MAPTMEN1KMT2A | |
| SCHEMBL6576328 | 0.81 | GPR84 (0.55) | AKR1A1AKR1B1TRPM8KMT2AHTR1A | |
| SCHEMBL6576362 | 0.79 | AKR1A1 (0.56) | AKR1A1AKR1B1HTR1D | |
| SCHEMBL6576292 | 0.79 | AKR1A1 (0.56) | AKR1A1AKR1B1TRPM8 | |
| SCHEMBL29007183 | 0.77 | TRPM8 (0.76) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL29617411 | 0.77 | TRPM8 (0.76) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL419033 | 0.77 | AKR1A1 (1.00) | AKR1A1AKR1B1 | |
| SCHEMBL24183187 | 0.76 | TRPM8 (0.74) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL6575507 | 0.75 | AKR1A1 (0.55) | AKR1A1AKR1B1 | |
| SCHEMBL6578352 | 0.73 | AKR1A1 (0.54) | AKR1A1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135124-B1 | ANTIHYPERTRIGLYCERIDEMIC, ANTIHYPERGLYCEMIC, ANTI-ANGIOGENIC AND WOUND HEALING SUBSTITUDED INDOLEALKANOIC ACIDS | INST FOR PHARM DISCOVERY INC (US) | 2004-04-28 | — | — | EP | disclosed |
| EP-1066283-A2 | SUBSTITUTED INDOLEALKANOIC ACIDS | The Institutes for Pharmaceutical Discovery, Inc. (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999050268-A2 | SUBSTITUTED INDOLEALKANOIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, INC. (US) | 1999-10-07 | — | — | WO | disclosed |