Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CPA1 | P15085 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6796596 | 0.83 | KDM4E (0.46) | OPRM1HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL27847679 | 0.72 | MAOA (0.36) | HSD11B1DPP4MAOAMAOBCPA1 | |
| SCHEMBL6060766 | 0.71 | HPGD (0.38) | HSD11B1OPRM1OPRL1DPP4MAOA | |
| SCHEMBL1841591 | 0.69 | LMNA (0.46) | HSD11B1MAOAMAOBALDH1A1CYP3A4 | |
| SCHEMBL9314420 | 0.69 | HSD11B1 (0.41) | HSD11B1MAOAMAOB | |
| SCHEMBL2204407 | 0.69 | ALDH1A1 (0.36) | HSD11B1DPP4HTTALDH1A1ADRB2 | |
| SCHEMBL21611368 | 0.69 | KDM1A (0.41) | HSD11B1OPRM1OPRL1MAOAMAOB | |
| SCHEMBL16167219 | 0.68 | AKR1C3 (0.38) | HSD11B1OPRM1OPRL1MAOAMAOB | |
| SCHEMBL28986817 | 0.67 | ADAM17 (0.46) | HSD11B1OPRM1OPRL1MAOAMAOB | |
| SCHEMBL7447229 | 0.66 | KDM4E (0.40) | ALDH1A1SMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1146044-B1 | CNS active cyclobuta-indole carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2004-09-01 | — | — | EP | disclosed |
| CN-1323796-A | Novel cyclobutaneindazol carboxylamine compound, their prepn. method and pharmaceutical compositions | ADIR (FR) | 2001-11-28 | — | — | CN | disclosed |
| EP-1146044-A1 | CNS active cyclobuta-indole carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-10-17 | — | — | EP | disclosed |