Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586735 | 0.81 | MAPT (0.44) | GNAI3GNAO1GNAI1SMN1; SMN2MAPT | |
| SCHEMBL6584534 | 0.76 | CXCR3 (0.45) | ACHEGNAI3GNAO1GNAI1SMN1; SMN2 | |
| SCHEMBL6585178 | 0.73 | SMN1; SMN2 (0.42) | GNAI3GNAO1GNAI1SMN1; SMN2CHRM5 | |
| SCHEMBL6586007 | 0.73 | POLB (0.47) | MAPTGAATHRB | |
| SCHEMBL2673448 | 0.73 | CHRM5 (0.48) | ACHEGNAI3GNAO1GNAI1SMN1; SMN2 | |
| SCHEMBL8100117 | 0.73 | CHRM5 (0.48) | ACHEGNAI3GNAO1GNAI1SMN1; SMN2 | |
| SCHEMBL7839825 | 0.73 | HTR1A (0.46) | GNAI3GNAO1GNAI1SMN1; SMN2MAPT | |
| SCHEMBL16900146 | 0.72 | NCF1 (0.50) | ACHEGNAI3GNAO1GNAI1CHRM5 | |
| SCHEMBL22940150 | 0.72 | GNAI3 (0.44) | ACHEGNAI3GNAO1GNAI1SMN1; SMN2 | |
| SCHEMBL6585893 | 0.72 | HTR4 (0.43) | MAPTGAATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076055-B1 | 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS | DAINIPPON PHARMACEUTICAL CO (JP) | 2004-11-24 | — | — | EP | disclosed |
| US-6294555-B1 | SEROTONIN HT3 RECEPTOR ANTAGONIST FOR GASTROINTESTINAL DISORDERS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2001-09-25 | — | — | US | disclosed |
| EP-1076055-A1 | 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 2001-02-14 | — | — | EP | disclosed |