SCHEMBL6589682

SCHEMBL6589682

Cc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cc2)c1N

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.60
P2RX1 P51575 4/20 0.56
HDAC1 Q13547 1/20 0.55
HDAC8 Q9BY41 1/20 0.55
HDAC6 Q9UBN7 1/20 0.55
FADS1 O60427 1/20 0.51
NPC1 O15118 1/20 0.51
RAB9A P51151 1/20 0.51
F10 P00742 3/20 0.50
MAPK1 P28482 2/20 0.48
MAPT P10636 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
ALDH1A1 P00352 2/20 0.48
LMNA P02545 1/20 0.48
POLB P06746 1/20 0.48
TMPRSS4 Q9NRS4 2/20 0.48
PTGS1 P23219 1/20 0.48
TBXAS1 P24557 1/20 0.48
PTGS2 P35354 1/20 0.48
MAPK14 Q16539 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6591408 0.82 ALDH1A1 (0.63) P2RX1HDAC8NPC1RAB9AF10
SCHEMBL6261356 0.82 RAB9A (0.64) NPC1RAB9AF10ALDH1A1
SCHEMBL6592137 0.82 HPGD (0.53) P2RX1HDAC1HDAC8HDAC6NPC1
SCHEMBL384330 0.79 KDM4E (0.42) BCL2L1HDAC1FADS1ALDH1A1
SCHEMBL27930599 0.79 ALDH1A1 (0.51) BCL2L1FADS1MAPTALDH1A1LMNA
Hydrochloric Acid SCHEMBL30808427 0.78 KDM4E (0.41) BCL2L1HDAC1FADS1ALDH1A1
SCHEMBL6587131 0.78 FADS1 (0.74) P2RX1HDAC1FADS1ALDH1A1LMNA
SCHEMBL26603550 0.77 KDM4E (0.46) BCL2L1FADS1MAPK1MAPTNPSR1
SCHEMBL14697698 0.76 PTGS2 (0.41) BCL2L1FADS1MAPTALDH1A1LMNA
SCHEMBL10396358 0.76 MEN1 (0.49) RAB9AMAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1143855-C I (ortho)-anthranilamide derivatives as anti-coagulants ���ֹɷݹ�˾ 2004-03-31 CN disclosed
EP-1040108-B1 ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS SCHERING AG (DE) 2004-02-25 EP disclosed
US-6498185-B1 ENZYME FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. 2002-12-24 US disclosed
US-6380221-B1 FOR THERAPY OF DISEASE-STATES CHARACTERIZED BY THROMBOTIC ACTIVITY BERLEX LABORATORIES, INC. 2002-04-30 US disclosed
CN-1282329-A I (ortho)-anthranilamide derivatives as anti-coagulants SCHERING AG (DE) 2001-01-31 CN disclosed
US-6140351-A FOR TREATING THROMBOSIS BERLEX LABORATORIES, INC. (US) 2000-10-31 US disclosed