SCHEMBL6599090

SCHEMBL6599090

COc1nn(-c2ccc(NCc3c(F)c(F)c(F)c(F)c3F)cc2)c(=O)o1

nearest known ligand 0.62

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ABHD16A O95870 2/20 0.62
MGLL Q99685 5/20 0.51
FAAH O00519 4/20 0.51
LPL P06858 1/20 0.50
LIPC P11150 1/20 0.50
LIPE Q05469 1/20 0.50
ABHD6 Q9BV23 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6603229 0.78 ABHD16A (0.52) ABHD16AMGLLFAAHLPLLIPC
SCHEMBL6601929 0.77 ABHD16A (0.50) ABHD16AMGLLFAAHLPLLIPC
SCHEMBL6600012 0.76 MGLL (0.51) ABHD16AMGLLFAAHLPLLIPC
SCHEMBL6599576 0.75 ABHD16A (0.54) ABHD16AMGLLFAAHLPLLIPC
Trifluoroacetic Acid SCHEMBL6601589 0.74 ABHD16A (0.47) ABHD16AMGLLFAAHLPLLIPC
Trifluoroacetic Acid SCHEMBL6599708 0.72 LPL (0.46) ABHD16AMGLLFAAHLPLLIPC
Trifluoroacetic Acid SCHEMBL6606875 0.72 MGLL (0.50) ABHD16AMGLLFAAHLPLLIPC
SCHEMBL6602421 0.72 MGLL (0.54) ABHD16AMGLLFAAHLPLLIPC
SCHEMBL2233598 0.72 ABHD16A (0.72) ABHD16AMGLLFAAHLPLLIPC
SCHEMBL11620781 0.72 FAAH (0.78) ABHD16AMGLLFAAHLPLLIPC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1263745-B1 SUBSTITUTED 3-PHENYL-5-ALKOXI-1,3,4-OXDIAZOL-2-ONE AND USE THEREOF FOR INHIBITING HORMONE-SENSITIVE LIPASE AVENTIS PHARMA GMBH (DE) 2004-05-19 EP disclosed