Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.37 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18282491 | 0.95 | CA2 (0.48) | CA2CA4SLC22A16MEN1KMT2A | |
| SCHEMBL2874716 | 0.75 | ALDH1A1 (0.43) | KMT2ATHRB | |
| SCHEMBL1878811 | 0.75 | ALDH1A1 (0.43) | KMT2ATHRB | |
| SCHEMBL202165 | 0.75 | SLC22A6 (0.39) | CYP2C19FFAR3THRB | |
| SCHEMBL4137634 | 0.73 | ALOX15 (0.40) | MEN1KMT2ACYP1A2THRB | |
| SCHEMBL21081924 | 0.73 | ALDH1A1 (0.40) | FFAR3THRB | |
| SCHEMBL10085240 | 0.73 | TSHR (0.36) | THRB | |
| SCHEMBL4483900 | 0.73 | TDP1 (0.43) | FFAR3THRB | |
| SCHEMBL9548177 | 0.73 | CA2 (0.50) | CA2CA4SLC22A16MEN1KMT2A | |
| Potassium Ion SCHEMBL1693886 | 0.72 | CYP3A4 (0.40) | CA2CA4FFAR3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9149791-B2 | Water-soluble carbohydrate polyethers | TRGel, LLC (US) | 2015-10-06 | — | — | US | disclosed |
| US-20120046435-A1 | Water-Soluble Carbohydrate Polyethers | GORKOVENKO ALEXANDER A (US) | 2012-02-23 | — | — | US | disclosed |