Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | PRF1 | P14222 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TYMS | P04818 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605649 | 0.84 | MAOA (0.55) | MAOAMAOBPRF1MAPTLMNA | |
| SCHEMBL15466341 | 0.81 | MAOA (0.41) | MAOAMAOBPRF1MAPTLMNA | |
| Isoquinoline SCHEMBL252739 | 0.78 | MAOB (0.62) | MAOAMAOBPRF1MAPTLMNA | |
| SCHEMBL6615574 | 0.76 | ROCK2 (0.54) | ROCK2AAK1ROCK1 | |
| SCHEMBL4787433 | 0.74 | CYP1A2 (0.41) | MAOAMAOBROCK2AAK1CYP1A2 | |
| Hydrochloric Acid SCHEMBL28271208 | 0.72 | MAOA (0.91) | MAOAMAOBPRF1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL28935107 | 0.72 | MAOA (0.91) | MAOAMAOBPRF1MAPTLMNA | |
| SCHEMBL6903786 | 0.72 | MAOA (1.00) | MAOAMAOBPRF1MAPTLMNA | |
| SCHEMBL6353583 | 0.72 | MAOA (1.00) | MAOAMAOBPRF1MAPTLMNA | |
| SCHEMBL22284 | 0.72 | MAOA (1.00) | MAOAMAOBPRF1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0140833-B1 | 5- AND 6-AZAPHTHALIDES, THEIR MIXTURE OF ISOMERS, PROCESS FOR THEIR PRODUCTION AND THEIR USE IN RECORDING MATERIALS WHICH ARE SENSITIVE TO PRESSURE AND HEAT | CIBA-GEIGY AG (CH) | 1988-03-02 | — | — | EP | claimed |
| JP-7278452-A | — | — | None | — | — | JP | disclosed |
| US-10759795-B2 | Aza-A-ring indenoisoquinoline topoisomerase I poisons | PURDUE RESEARCH FOUNDATION (US) | 2020-09-01 | — | — | US | disclosed |
| US-10759795-B2 | Aza-A-ring indenoisoquinoline topoisomerase I poisons | PURDUE RESEARCH FOUNDATION (US) | 2020-09-01 | — | — | US | disclosed |
| US-10233191-B2 | Fused piperidine amides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-03-19 | — | — | US | disclosed |
| US-10233191-B2 | Fused piperidine amides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-03-19 | — | — | US | disclosed |
| WO-2017160898-A1 | AZA-A-RING INDENOISOQUINOLINE TOPOISOMERASE I POISONS | PURDUE RESEARCH FOUNDATION (US) | 2017-09-21 | — | — | WO | disclosed |
| WO-2017160898-A1 | AZA-A-RING INDENOISOQUINOLINE TOPOISOMERASE I POISONS | PURDUE RESEARCH FOUNDATION (US) | 2017-09-21 | — | — | WO | disclosed |
| US-9539307-B2 | Compositions and methods for treating amyotrophic lateral sclerosis | THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (US) | 2017-01-10 | — | — | US | disclosed |
| US-20160159815-A1 | Fused Piperidine Amides as Modulators of Ion Channels | VERTEX PHARMACEUTICALS INCORPORATED | 2016-06-09 | — | — | US | disclosed |
| US-6710047-B2 | INHIBIT THE ACTIVITY OF THE VEGF RECEPTOR TYROSINE KINASE AND THE GROWTH OF TUMOURS | NOVARTIS AG (CH) | 2004-03-23 | — | — | US | disclosed |
| US-20030191129-A1 | Phthalazines with angiogenesis inhibiting activity | BOLD GUIDO (CH) | 2003-10-09 | — | — | US | disclosed |
| US-6514974-B2 | 1-(4-Chloroanilino)-4-(4-pyridylmethyl)phthalazine for example | NOVARTIS AG (CH) | 2003-02-04 | — | — | US | disclosed |
| US-20020091261-A1 | Phthalazines with angiogenesis inhibiting activity | BOLD GUIDO (CH) | 2002-07-11 | — | — | US | disclosed |
| JP-H07278452-A | PRODUCTION OF 5-AZAPHTHALIDE DERIVATIVE | FUJI PHOTO FILM CO LTD | 1995-10-24 | — | — | JP | disclosed |
| US-5369084-A | Isonicotinic acid derivatives and related spiro compounds with herbicidal action | JANSSEN PHARMACEUTICAL N.V. (BE) | 1994-11-29 | — | — | US | disclosed |
| WO-1992009577-A1 | ISONICOTINIC ACID DERIVATIVES AND RELATED SPIRO COMPOUNDS WITH HERBICIDAL ACTION | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-06-11 | — | — | WO | disclosed |
| US-4337340-A | FROM DIPHENYLAMINES AND BENZOYL OR 3-INDOLYLCARBONYL PYRIDINE- OR PYRAZINECARBOXYLIC ACIDS | STERLING DRUG INC. (US) | 1982-06-29 | — | — | US | disclosed |
| US-4243250-A | FUROPYRIDINONES OR FUROPYRAZINONES AS COLOR FORMERS | STERLING DRUG INC. (US) | 1981-01-06 | — | — | US | disclosed |
| US-4211872-A | COLOR FORMERS | FREEDOM CHEMICAL COMPANY | 1980-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030191129-A1 | Phthalazines with angiogenesis inhibiting activity | PGF, VEGFA, FLT4 | MAOA 694/4885MAOB 464/4885PRF1 3729/4885 |
| US-10759795-B2 | Aza-A-ring indenoisoquinoline topoisomerase I poisons | TOP1, TOP2A, TOP2B | MAOA 1076/4885MAOB 1285/4885PRF1 1049/4885 |
| US-10233191-B2 | Fused piperidine amides as modulators of ion channels | TRPV1, TRPA1, KCNJ2 | MAOA 2734/4885MAOB 3125/4885PRF1 3143/4885 |
| US-20160159815-A1 | Fused Piperidine Amides as Modulators of Ion Channels | TRPV1, TRPA1, KCNJ2 | MAOA 2734/4885MAOB 3125/4885PRF1 3143/4885 |
| US-20020091261-A1 | Phthalazines with angiogenesis inhibiting activity | PGF, VEGFA, FLT4 | MAOA 675/4885MAOB 440/4885PRF1 3521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.