SCHEMBL6638564

SCHEMBL6638564

Cn1c(C(F)(F)F)cc(=O)n(-c2cc(Oc3nccc(OCc4ccccc4)n3)c(Cl)cc2F)c1=O

nearest known ligand 0.34

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PLA2G7 Q13093 11/20 0.34
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
ALDH1A1 P00352 1/20 0.33
RHEB Q15382 1/20 0.33
PKM P14618 2/20 0.32
BCAT1 P54687 3/20 0.32
BCAT2 O15382 2/20 0.32
GRM4 Q14833 1/20 0.32
MAOA P21397 1/20 0.32
MAOB P27338 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6637976 0.90 PLA2G7 (0.36) PLA2G7MEN1KMT2AALDH1A1RHEB
SCHEMBL8926019 0.85 PPOX (0.40) MEN1KMT2AALDH1A1RHEBBCAT1
SCHEMBL6641762 0.85 LMNA (0.32) LMNA
SCHEMBL1527259 0.85 BCAT1 (0.39) MEN1KMT2AALDH1A1RHEBBCAT1
SCHEMBL7237202 0.84 TRIM24 (0.39) PLA2G7MEN1KMT2AALDH1A1PKM
SCHEMBL6639714 0.84 PPOX (0.41) PLA2G7MEN1KMT2APKM
SCHEMBL10579206 0.84 BCAT1 (0.35) ALDH1A1BCAT1BCAT2GRM4
SCHEMBL6641269 0.83 BCAT1 (0.32) BCAT1BCAT2GRM4
SCHEMBL6639038 0.83 MEN1 (0.35) MEN1KMT2AALDH1A1RHEBBCAT1
SCHEMBL6640947 0.83 ALDH1A1 (0.34) PLA2G7MEN1KMT2AALDH1A1RHEB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1122244-B1 Uracil compounds and their use SUMITOMO CHEMICAL CO (JP) 2004-09-29 EP disclosed
US-6537948-B1 Have a wide range of herbicidal spectrum, and causes no phytotoxicity on crops SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-03-25 US disclosed
EP-1122244-A1 Uracil compounds and their use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-08-08 EP disclosed