SCHEMBL6654574

SCHEMBL6654574

FC(F)(F)c1c[c]c(C(F)(F)F)nc1

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.33
ALDH1A1 P00352 2/20 0.32
GLA P06280 1/20 0.30
HPGD P15428 1/20 0.30
PLAU P00749 1/20 0.30
KDM4E B2RXH2 1/20 0.30
POLB P06746 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
AGBL2 Q5U5Z8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5142181 0.77 KMT2A (0.33) KMT2AALDH1A1GLAHPGDPLAU
SCHEMBL28593483 0.77
SCHEMBL791025 0.76 AGBL2 (0.36) KMT2AALDH1A1HPGDKDM4EPOLB
SCHEMBL7968781 0.76 HTT (0.34)
SCHEMBL28713868 0.76 NOS3 (0.36) KMT2AALDH1A1PLAUKDM4EPOLB
SCHEMBL4472993 0.76 TRPV1 (0.31)
SCHEMBL790734 0.76 ALDH1A1 (0.40) KMT2AALDH1A1GLAHPGDPLAU
SCHEMBL17979223 0.71
SCHEMBL21810854 0.71 SMN1; SMN2 (0.37) KMT2AHPGDKDM4ESMN1; SMN2AGBL2
SCHEMBL28887006 0.71 KIF11 (0.33) KMT2APOLBAGBL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240041854-A1 COLD MEDICINE AND ANTIVIRAL MEDICINE OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 2024-02-08 US disclosed
EP-4190329-A1 COLD REMEDY AND ANTIVIRAL AGENT Otsuka Pharmaceutical Factory, Inc. (JP) 2023-06-07 EP disclosed
EP-1417202-A2 AMINOPIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY F. HOFFMANN-LA ROCHE AG (CH) 2004-05-12 EP disclosed
US-20030069276-A1 Amino piperidine derivatives F.HOFFMANN-LA ROCHE AG (CH) 2003-04-10 US disclosed
WO-2002079186-A2 AMINOPIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY F. HOFFMANN-LA ROCHE AG (CH) 2002-10-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240041854-A1 COLD MEDICINE AND ANTIVIRAL MEDICINE IRF3, MAVS, EIF2AK2 KMT2A 3581/4885ALDH1A1 1236/4885GLA 2317/4885
US-20030069276-A1 Amino piperidine derivatives CCR5, CCR2, CXCR4 KMT2A 3009/4885ALDH1A1 1935/4885GLA 4873/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.