SCHEMBL790734

SCHEMBL790734

FC(F)(F)c1c[c]c(Cl)nc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.40
SMN1; SMN2 Q16637 4/20 0.40
POLB P06746 2/20 0.40
KDM4E B2RXH2 2/20 0.40
PLAU P00749 1/20 0.36
GLA P06280 1/20 0.36
HPGD P15428 1/20 0.36
NPC1 O15118 4/20 0.36
RAB9A P51151 4/20 0.36
MAPK1 P28482 1/20 0.36
HTT P42858 3/20 0.35
MAPT P10636 2/20 0.35
GAA P10253 2/20 0.34
KMT2A Q03164 2/20 0.34
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
LMNA P02545 1/20 0.33
PKM P14618 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5142181 0.76 KMT2A (0.33) ALDH1A1SMN1; SMN2POLBKDM4EPLAU
SCHEMBL6654574 0.76 KMT2A (0.33) ALDH1A1SMN1; SMN2POLBKDM4EPLAU
SCHEMBL791025 0.74 AGBL2 (0.36) ALDH1A1SMN1; SMN2POLBKDM4EHPGD
SCHEMBL28713868 0.74 NOS3 (0.36) ALDH1A1SMN1; SMN2POLBKDM4EPLAU
SCHEMBL1043728 0.70
SCHEMBL28887006 0.69 KIF11 (0.33) POLBKMT2APKM
SCHEMBL21810854 0.69 SMN1; SMN2 (0.37) SMN1; SMN2KDM4EHPGDRAB9AMAPK1
SCHEMBL485196 0.69 NFKB1 (0.46) ALDH1A1SMN1; SMN2POLBKDM4EPLAU
SCHEMBL193034 0.69
SCHEMBL2790279 0.67 KMT2A (0.50) ALDH1A1SMN1; SMN2KDM4EPLAUGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114072395-A Heterocyclic compounds and their use for treating helminth infections and diseases 新基公司 2022-02-18 CN disclosed
EP-2923571-B1 HERBICIDE COMPOSITION SUMITOMO CHEMICAL CO (JP) 2017-04-26 EP disclosed
US-9414588-B2 Herbicide composition SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-08-16 US disclosed
US-20150289505-A1 HERBICIDE COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-10-15 US disclosed
EP-2923571-A1 HERBICIDE COMPOSITION Sumitomo Chemical Company Limited (JP) 2015-09-30 EP disclosed
EP-2615917-A2 PYRIDINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS III BASF SE (DE) 2013-07-24 EP disclosed
US-20130180014-A1 Pyridine Compounds for Controlling Invertebrate Pests III BASF SE (DE) 2013-07-11 US disclosed
US-8299262-B2 Pyridylmethyl-sulfonamide compounds BASF SE (DE) 2012-10-30 US disclosed
WO-2012034959-A2 PYRIDINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS III BASF SE (DE) 2012-03-22 WO disclosed
EP-2297134-A1 SUBSTITUTED PYRIDIN-4 -YL-METHYL SULFONAMIDES AS FUNGICIDES BASF SE (DE) 2011-03-23 EP disclosed
US-20100249077-A1 Pyridylmethyl-Sulfonamide Compounds BASF SE (DE) 2010-09-30 US disclosed
EP-2231605-A1 PYRIDYLMETHYL-SULFONAMIDE COMPOUNDS BASF SE (DE) 2010-09-29 EP disclosed
WO-2009141292-A1 SUBSTITUTED HETEROARYLMETHYL SULFONAMIDES BASF SE (DE) 2009-11-26 WO disclosed
WO-2009141274-A1 SUBSTITUTED PYRIDIN-4 -YL-METHYL SULFONAMIDES AS FUNGICIDES BASF SE (DE) 2009-11-26 WO disclosed
WO-2009112533-A1 SUBSTITUTED TRIAZINYLMETHYL SULFONAMIDES BASF SE (DE) 2009-09-17 WO disclosed
WO-2009071448-A1 PYRIDYLMETHYL-SULFONAMIDE COMPOUNDS BASF SE (DE) 2009-06-11 WO disclosed
WO-2009071449-A1 PYRIDYLMETHYL-SULFONAMIDE COMPOUNDS BASF SE (DE) 2009-06-11 WO disclosed
EP-0617011-B1 Process for producing alkoxyiminoacetamide compounds SHIONOGI & CO (JP) 1999-01-20 EP disclosed
US-5506358-A USEFUL AS AGRICULTURAL FUNGICIDES SHIONOGI & CO., LTD. (JP) 1996-04-09 US disclosed
EP-0617011-A2 Process for producing alkoxyiminoacetamide compounds SHIONOGI & CO., LTD. (JP) 1994-09-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150289505-A1 HERBICIDE COMPOSITION DDT, DHFR, DERL1 ALDH1A1 215/4885SMN1; SMN2 4644/4885POLB 2318/4885
US-20130180014-A1 Pyridine Compounds for Controlling Invertebrate Pests III CHRM1, CHRM2, GRIN2C ALDH1A1 1153/4885SMN1; SMN2 1928/4885POLB 4137/4885
US-20100249077-A1 Pyridylmethyl-Sulfonamide Compounds CBR3, CBR1, CBS ALDH1A1 1178/4885SMN1; SMN2 3215/4885POLB 3230/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.