Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 8/20 | 0.62 |
| ▸ | MMP2 | P08253 | 5/20 | 0.62 |
| ▸ | MMP12 | P39900 | 5/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8231076 | 0.87 | MMP9 (0.65) | MMP9MMP2MMP12CYP2C9CYP2C19 | |
| SCHEMBL6659000 | 0.85 | MMP9 (0.53) | MMP9MMP2MMP12CYP2C9CYP2C19 | |
| SCHEMBL6660771 | 0.84 | MMP9 (0.44) | MMP9MMP2MMP12CYP2C9CYP2C19 | |
| SCHEMBL6654463 | 0.84 | ADAM17 (0.47) | MMP9MMP2MMP12CYP2C9CYP2C19 | |
| SCHEMBL6656390 | 0.84 | ADAM17 (0.44) | MMP9MMP2MMP12CYP2C9CYP2C19 | |
| SCHEMBL6657084 | 0.84 | MMP9 (0.44) | MMP9MMP2MMP12CYP2C9CYP2C19 | |
| SCHEMBL315440 | 0.80 | MMP2 (0.92) | MMP9MMP2MMP12CYP2C9CYP2C19 | |
| SCHEMBL6657407 | 0.80 | MMP9 (0.46) | MMP9MMP2MMP12CYP2C9CYP2C19 | |
| SCHEMBL8363035 | 0.79 | MMP2 (0.71) | MMP9MMP2MMP12CYP2C9CYP2C19 | |
| SCHEMBL6655282 | 0.78 | PTGS2 (0.57) | ADAM17SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | disclosed |
| US-20020147342-A1 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors | AMERICAN CYANAMID COMPANY (US) | 2002-10-10 | — | — | US | disclosed |
| US-6340691-B1 | TREATMENT OF ARTHRITIS, TUMOR METASTASIS, TISSUE ULCERATION, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, DIABETES (INSULIN RESISTANCE) AND HIV INFECTION | AMERICAN CYANAMID COMPANY | 2002-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020147342-A1 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors | MMP12, MMP17, MMP14 | MMP9 14/4885MMP2 22/4885MMP12 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.