Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA known ✓ | P10827 | 1/20 | 0.47 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.47 |
| ▸ | ALOX5 known ✓ | P09917 | 1/20 | 0.40 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.40 |
| ▸ | PPARG known ✓ | P37231 | 1/20 | 0.40 |
| ▸ | CYSLTR1 known ✓ | Q9Y271 | 2/20 | 0.38 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ether SCHEMBL3979282 | 1.00 | FUT7 (0.48) | FUT7THRATHRBPPARALIPG | |
| Ether SCHEMBL1094885 | 1.00 | FUT7 (0.48) | FUT7THRATHRBPPARALIPG | |
| Ether SCHEMBL3235371 | 0.97 | THRA (0.48) | FUT7THRATHRBPPARALIPG | |
| Ether SCHEMBL8746880 | 0.97 | THRA (0.47) | FUT7THRATHRBPPARALIPG | |
| SCHEMBL2322031 | 0.94 | FUT7 (0.52) | FUT7THRATHRBPPARALIPG | |
| SCHEMBL1457335 | 0.94 | FUT7 (0.52) | FUT7THRATHRBPPARALIPG | |
| Potassium Ion SCHEMBL29019107 | 0.92 | THRA (0.51) | FUT7THRATHRBPPARALIPG | |
| Ether SCHEMBL1712535 | 0.85 | THRA (0.51) | THRATHRBPPARALIPGALOX5 | |
| Ether SCHEMBL515387 | 0.85 | THRA (0.51) | THRATHRBPPARALIPGALOX5 | |
| Ether SCHEMBL2937392 | 0.85 | THRA (0.51) | THRATHRBPPARALIPGALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112262177-B | Polyvinyl alcohol film and polarizing film | 三菱化学株式会社 | 2023-08-22 | — | — | CN | disclosed |
| EP-1448069-A1 | DETERIORATION PREVENTIVE AGENT | Takasago International Corporation (JP) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003041517-A1 | DETERIORATION PREVENTIVE AGENT | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2003-05-22 | — | — | WO | disclosed |
| US-4182621-A | 6-HYDRPXY-3-(2H)-PYRIDAZINONE | OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA (JP) | 1980-01-08 | — | — | US | disclosed |