Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200591 | 0.88 | BRD4 (0.36) | POLBBRD4P2RY2MAPTNPSR1 | |
| SCHEMBL6200596 | 0.82 | BRD4 (0.37) | POLBBRD4P2RY2MAPTNPSR1 | |
| SCHEMBL6671910 | 0.81 | P2RX3 (0.36) | POLBMAPTNPSR1ACVR1BTGFBR1 | |
| SCHEMBL6672316 | 0.81 | NR3C1 (0.37) | MAPTCNR2NR3C1LMNA | |
| SCHEMBL6195418 | 0.80 | TRPA1 (0.39) | MAPTNPSR1ACVR1BTGFBR1ACVRL1 | |
| SCHEMBL6197930 | 0.80 | POLB (0.45) | POLBBRD4P2RY2MAPTNPSR1 | |
| SCHEMBL6201678 | 0.79 | GAA (0.37) | POLBMAPTACVR1BTGFBR1ACVRL1 | |
| Trifluoroacetic Acid SCHEMBL6672935 | 0.79 | LMNA (0.36) | POLBMAPTCNR1CNR2NR3C1 | |
| SCHEMBL6666974 | 0.75 | LMNA (0.39) | POLBMAPTKMT2AMEN1CNR2 | |
| SCHEMBL6201682 | 0.74 | GAA (0.36) | POLBMAPTACVR1BTGFBR1ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004019932-A1 | METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| WO-2004019932-A1 | METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-11 | — | — | WO | disclosed |