SCHEMBL6672072

SCHEMBL6672072

CCc1ccc(C(C)[Si](C)(C)Cl)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.50
TDP1 Q9NUW8 2/20 0.50
TSHR P16473 1/20 0.50
MAPK1 P28482 1/20 0.50
ATM Q13315 1/20 0.50
ALDH1A1 P00352 3/20 0.38
MAPT P10636 1/20 0.38
PKM P14618 1/20 0.38
HTT P42858 1/20 0.38
HSD17B10 Q99714 1/20 0.38
RAB9A P51151 2/20 0.37
NPC1 O15118 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2D6 P10635 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
TP53 P04637 1/20 0.36
TAAR1 Q96RJ0 1/20 0.35
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
AKR1C3 P42330 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6668079 0.83 ESR1 (0.35) L3MBTL1TDP1TSHRMAPK1ATM
SCHEMBL28437151 0.73 L3MBTL1 (0.44) L3MBTL1TDP1TSHRMAPK1ATM
SCHEMBL5491106 0.73 L3MBTL1 (0.48) L3MBTL1TDP1TSHRMAPK1ATM
SCHEMBL3799465 0.73 ADRA2A (0.43) TSHRALDH1A1CYP2D6TAAR1LMNA
SCHEMBL8750481 0.73 TSHR (0.64) L3MBTL1TDP1TSHRMAPK1ATM
SCHEMBL9228424 0.72 ESR1 (0.36) L3MBTL1TDP1TSHRMAPK1ATM
SCHEMBL29262161 0.72 L3MBTL1 (0.57) L3MBTL1TDP1TSHRMAPK1ATM
SCHEMBL139408 0.72 L3MBTL1 (0.56) L3MBTL1TDP1TSHRMAPK1ATM
SCHEMBL500563 0.72 TSHR (0.56) L3MBTL1TDP1TSHRMAPK1ATM
SCHEMBL147032 0.70 TSHR (0.67) L3MBTL1TDP1TSHRMAPK1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0969007-B1 Method of making an aromatic chlorosilane compound by a hydrosilation reaction DOW CORNING ASIA LTD (JP) 2004-09-22 EP disclosed
US-6054602-A Method of making an aromatic chlorosilane compound by a hydrosilation reaction DOW CORNING ASIA, LTD. (JP) 2000-04-25 US disclosed
EP-0969007-A2 Method of making an aromatic chlorosilane compound by a hydrosilation reaction Dow Corning Asia, Ltd. (JP) 2000-01-05 EP disclosed