SCHEMBL668064

SCHEMBL668064

COc1ccc(C(OC[C@H]2O[C@@H](n3ccc(NC(C)=O)nc3=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TYMP P19971 2/20 0.35
P2RY6 Q15077 3/20 0.32
P2RY14 Q15391 2/20 0.32
NT5E P21589 1/20 0.32
P2RY2 P41231 1/20 0.31
P2RY4 P51582 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29195406 0.94 TYMP (0.37) TYMPP2RY6P2RY14NT5EP2RY2
SCHEMBL667613 0.94 TYMP (0.37) TYMPP2RY6P2RY14NT5EP2RY2
SCHEMBL26535949 0.94 TYMP (0.37) TYMPP2RY6P2RY14NT5EP2RY2
SCHEMBL3915198 0.94 TYMP (0.37) TYMPP2RY6P2RY14NT5EP2RY2
SCHEMBL13715722 0.94 TYMP (0.37) TYMPP2RY6P2RY14NT5EP2RY2
SCHEMBL24878606 0.94 TYMP (0.37) TYMPP2RY6P2RY14NT5EP2RY2
SCHEMBL31229956 0.94 TYMP (0.37) TYMPP2RY6P2RY14NT5EP2RY2
SCHEMBL12765879 0.92 TYMP (0.34) TYMPP2RY6P2RY14NT5EP2RY2
SCHEMBL16315472 0.92 TYMP (0.34) TYMPP2RY6P2RY2P2RY4
SCHEMBL6518721 0.92 TYMP (0.35) TYMPP2RY6P2RY14NT5EP2RY2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109863161-B Labeled polynucleotides useful for nucleic acid sequencing 豪夫迈·罗氏有限公司 2022-06-03 CN claimed
US-20260117285-A1 COMPOSITIONS AND METHODS FOR IMPROVING LIBRARY ENRICHMENT ILLUMINA INC (US) 2026-04-30 US disclosed
US-12473594-B2 Chemical tagging-based method for modified nucleoside sequencing, enrichment, and measurement PEKING UNIVERSITY (CN) 2025-11-18 US disclosed
US-12435362-B2 Compositions and methods for improving library enrichment ILLUMINA, INC. (US) 2025-10-07 US disclosed
CN-112955568-B Compositions and methods for improving library enrichment ILLUMINA公司 2025-05-16 CN disclosed
US-20240264142-A1 MOLECULAR DETECTION AND COUNTING USING NANOPORES ROCHE SEQUENCING SOLUTIONS INC (US) 2024-08-08 US disclosed
US-20230332219-A1 CHEMICAL TAGGING-BASED METHOD FOR MODIFIED NUCLEOSIDE SEQUENCING, ENRICHMENT, AND MEASUREMENT PEKING UNIVERSITY (CN) 2023-10-19 US disclosed
US-20230323343-A1 CLOSED LINEAR DNA WITH MODIFIED NUCLEOTIDES TYRIS THERAPEUTICS, S.L. (ES) 2023-10-12 US disclosed
CN-110603330-B Oligonucleotide derivative or salt thereof 协和麒麟株式会社 2023-09-05 CN disclosed
EP-3617314-B1 OLIGONUCLEOTIDE DERIVATIVE OR SALT THEREOF KYOWA KIRIN CO LTD (JP) 2023-02-15 EP disclosed
US-20060223770-A1 IRNA agents targeting VEGF ALNYLAM EUROPE AG (DE) 2006-10-05 US disclosed
US-20060217330-A1 Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering RNAs BANK OF AMERICA, N.A. 2006-09-28 US disclosed
US-20060094032-A1 iRNA agents targeting VEGF ALNYLAM PHARMACEUTICALS, INC. 2006-05-04 US disclosed
US-20050267300-A1 Processes and reagents for oligonucleotide synthesis and purification ALNYLAM PHARMACEUTICALS 2005-12-01 US disclosed
US-20050059817-A1 Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives SIRNA THERAPEUTICS, INC. (US) 2005-03-17 US disclosed
US-6686463-B2 FEWER SYNTHETIC STEPS; INVOLVES FORMATION OF A 5',4'-BRIDGING SILYL PROTECTING GROUP TO FORM A FUSED SILOXANE ON THE FURAN RING SIRNA THERAPEUTICS, INC. 2004-02-03 US disclosed
EP-1313752-A2 METHODS FOR SYNTHESIZING NUCLEOSIDES, NUCLEOSIDE DERIVATIVES AND NON-NUCLEOSIDE DERIVATIVES RIBOZYME PHARMACEUTICALS, INC. (US) 2003-05-28 EP disclosed
US-20020150936-A1 Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives RIBOZYME PHARMACEUTICALS, INC. 2002-10-17 US disclosed
US-20020120129-A1 Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives RIBOZYME PHARMACEUTICALS, INC. 2002-08-29 US disclosed
WO-2002018405-A2 METHODS FOR SYNTHESIZING NUCLEOSIDES, NUCLEOSIDE DERIVATIVES AND NON-NUCLEOSIDE DERIVATIVES RIBOZYME PHARMACEUTICALS, INCORPORATED (US) 2002-03-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060094032-A1 iRNA agents targeting VEGF KDR, FLT4, SNRPE TYMP 1464/4885P2RY6 4719/4885P2RY14 4836/4885
US-20050059817-A1 Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives PNP, NSUN2, NT5C3B TYMP 16/4885P2RY6 712/4885P2RY14 694/4885
US-20230332219-A1 CHEMICAL TAGGING-BASED METHOD FOR MODIFIED NUCLEOSIDE SEQUENCING, ENRICHMENT, AND MEASUREMENT NT5C3B, BHMT2, NNMT TYMP 90/4885P2RY6 1712/4885P2RY14 3446/4885
US-12473594-B2 Chemical tagging-based method for modified nucleoside sequencing, enrichment, and measurement NT5C3B, BHMT2, NNMT TYMP 90/4885P2RY6 1712/4885P2RY14 3446/4885
US-20020120129-A1 Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives PNP, NSUN2, NT5C3B TYMP 17/4885P2RY6 700/4885P2RY14 854/4885
US-20060223770-A1 IRNA agents targeting VEGF KDR, FLT4, SNRPE TYMP 1464/4885P2RY6 4719/4885P2RY14 4836/4885
US-20260117285-A1 COMPOSITIONS AND METHODS FOR IMPROVING LIBRARY ENRICHMENT TTI1, MBNL1, UPF1 TYMP 94/4885P2RY6 1453/4885P2RY14 1603/4885
US-20020150936-A1 Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives PNP, NSUN2, NT5C3B TYMP 14/4885P2RY6 862/4885P2RY14 799/4885
US-20050267300-A1 Processes and reagents for oligonucleotide synthesis and purification RNGTT, ALKBH1, MTAP TYMP 26/4885P2RY6 328/4885P2RY14 624/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.