SCHEMBL668473

SCHEMBL668473

COC(=O)c1cccc(OC)c1CBr

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.49
MAPT P10636 2/20 0.49
TSHR P16473 2/20 0.49
HSD17B10 Q99714 2/20 0.49
MAPK1 P28482 1/20 0.49
CTSD P07339 1/20 0.47
ALDH1A1 P00352 3/20 0.46
KDM4E B2RXH2 2/20 0.46
SLC6A3 Q01959 1/20 0.45
HTT P42858 2/20 0.45
HSP90AA1 P07900 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
LMNA P02545 3/20 0.44
NPC1 O15118 1/20 0.44
KMT2A Q03164 3/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
POLB P06746 1/20 0.43
CFTR P13569 1/20 0.43
KCNK3 O14649 1/20 0.43
KCNK9 Q9NPC2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30429212 1.00 GAA (0.49) GAAMAPTTSHRHSD17B10MAPK1
SCHEMBL29041518 0.88 LMNA (0.52) GAAMAPTTSHRHSD17B10ALDH1A1
SCHEMBL29240004 0.87 SLC6A3 (0.43) GAAMAPTTSHRHSD17B10MAPK1
SCHEMBL30728867 0.86 MAPT (0.47) GAAMAPTTSHRHSD17B10MAPK1
SCHEMBL2252130 0.86 MAPK1 (0.46) GAAMAPTTSHRHSD17B10MAPK1
SCHEMBL24001525 0.85 HPGDS (0.44) GAAMAPTTSHRHSD17B10MAPK1
SCHEMBL2315524 0.85 HTT (0.53) TSHRHSD17B10MAPK1CTSDALDH1A1
SCHEMBL6828757 0.85 GAA (0.50) GAAMAPTTSHRHSD17B10MAPK1
SCHEMBL5837025 0.84 CHEK1 (0.48) GAAMAPTTSHRHSD17B10MAPK1
SCHEMBL9887730 0.83 GAA (0.49) GAAMAPTTSHRHSD17B10MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035354-A1 PIPERIDINEDIONE DERIVATIVES INNOCURE THERAPEUTICS, INC. (KR) 2026-02-05 US disclosed
EP-4640686-A1 DEGRADER FOR DEGRADING BRD PROTEIN AND PHARMACEUTICAL COMPOSITION CONTAINING SAME Innocure Therapeutics, Inc. (KR) 2025-10-29 EP disclosed
EP-4624466-A1 DEGRADER FOR DECOMPOSING CMET PROTEIN, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME Innocure Therapeutics, Inc. (KR) 2025-10-01 EP disclosed
EP-4624472-A1 DEGRADER INCLUDING NOVEL C-MET PROTEIN LIGAND AND PHARMACEUTICAL COMPOSITION INCLUDING SAME Innocure Therapeutics, Inc. (KR) 2025-10-01 EP disclosed
US-12384756-B2 Piperidinedione derivatives INNOCURE THERAPEUTICS, INC. (KR) 2025-08-12 US disclosed
US-12145941-B2 Heterocyclic antiviral agents ENANTA PHARMACEUTICALS, INC. (US) 2024-11-19 US disclosed
WO-2024127297-A1 3-FLUORO-4-HYDROXYBENZMIDE-CONTAINING INHIBITORS AND/OR DEGRADERS AND USES THEREOF PFIZER INC. (US) 2024-06-20 WO disclosed
WO-2024112120-A1 DEGRADER INCLUDING NOVEL C-MET PROTEIN LIGAND AND PHARMACEUTICAL COMPOSITION INCLUDING SAME 주식회사 이노큐어테라퓨틱스 2024-05-30 WO disclosed
WO-2024112120-A1 DEGRADER INCLUDING NOVEL C-MET PROTEIN LIGAND AND PHARMACEUTICAL COMPOSITION INCLUDING SAME 주식회사 이노큐어테라퓨틱스 2024-05-30 WO disclosed
WO-2024112122-A1 DEGRADER FOR DEGRADING BRD PROTEIN AND PHARMACEUTICAL COMPOSITION CONTAINING SAME 주식회사 이노큐어테라퓨틱스 2024-05-30 WO disclosed
WO-2004078924-A2 BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX RHEOGENE, INC. (US) 2004-09-16 WO disclosed
WO-2004073612-A2 ESTROGEN RECEPTOR MODULATORS MERCK & CO. INC. (US) 2004-09-02 WO disclosed
US-6747049-B2 NON-INSULIN DEPENDENT DIABETES MELLITUS. HOFFMANN-LA ROCHE INC. 2004-06-08 US disclosed
WO-2004005266-A1 OXAZOLE DERIVATIVES AND THEIR USE AS INSULIN SENSITIZERS F. HOFFMANN-LA ROCHE AG (CH) 2004-01-15 WO disclosed
US-20040006116-A1 Oxazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 2004-01-08 US disclosed
EP-1357120-A1 2-(2,6-dioxopiperidin-3-yl)isoindoline derivatives, their preparation and their use as inhibitors of inflammatory cytokines CELGENE CORPORATION (US) 2003-10-29 EP disclosed
US-20030028028-A1 1-oxo- and 1,3-dioxoisoindolines and method of reducing inflammatory cytokine levels CELGENE CORPORATION 2003-02-06 US disclosed
US-6403613-B1 ANTI-INFLAMMATORY AGENT THAT REDUCES LEVELS OF CYTOKINES (INCLUDING TUMOR NECROSIS FACTOR) CELGENE CORPORATION 2002-06-11 US disclosed
US-20010006973-A1 1-OXO- AND 1,3-DIOXOISOINDOLINES AND METHOD OF REDUCING INFLAMMATORY CYTOKINE LEVELS MAN HON-WAH (US) 2001-07-05 US disclosed
EP-0093488-A2 Nortropyl benzopyrrolinone compounds, process for their preparation and pharmaceutical compositions containing them BEECHAM GROUP PLC (GB) 1983-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035354-A1 PIPERIDINEDIONE DERIVATIVES CRBN, PSMC1, PSME3 GAA 4532/4885MAPT 4275/4885TSHR 2240/4885
US-12145941-B2 Heterocyclic antiviral agents ACE, SARS1, ACE2 GAA 224/4885MAPT 4242/4885TSHR 4421/4885
US-20010006973-A1 1-OXO- AND 1,3-DIOXOISOINDOLINES AND METHOD OF REDUCING INFLAMMATORY CYTOKINE LEVELS TNF, IL1A, IL1B GAA 4419/4885MAPT 4420/4885TSHR 3000/4885
US-20040006116-A1 Oxazole derivatives GPR119, IRS1, INSR GAA 690/4885MAPT 4699/4885TSHR 606/4885
US-20030028028-A1 1-oxo- and 1,3-dioxoisoindolines and method of reducing inflammatory cytokine levels TNF, IL1A, IL1B GAA 4419/4885MAPT 4420/4885TSHR 3000/4885
US-12384756-B2 Piperidinedione derivatives CRBN, CUL1, PSMB10 GAA 3836/4885MAPT 2906/4885TSHR 3860/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.