Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | S100A4 | P26447 | 2/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 2/20 | 0.33 |
| ▸ | NSD2 | O96028 | 2/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.33 |
| ▸ | PADI3 | Q9ULW8 | 1/20 | 0.33 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.33 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668836 | 0.79 | BRD4 (0.38) | BRD4S100A4CDC25BTDP2NSD2 | |
| SCHEMBL27713894 | 0.78 | BRD4 (0.37) | BRD4S100A4CDC25BTDP2NSD2 | |
| Hydrochloric Acid SCHEMBL27167121 | 0.78 | BRD4 (0.37) | BRD4S100A4CDC25BTDP2NSD2 | |
| Hydrochloric Acid SCHEMBL27167119 | 0.78 | BRD4 (0.37) | BRD4S100A4CDC25BTDP2NSD2 | |
| SCHEMBL10513637 | 0.71 | BRD4 (0.38) | BRD4TDP2NSD2PAX8ABL1 | |
| Quinoline SCHEMBL28279896 | 0.69 | ALDH1A1 (0.50) | MEN1KMT2ATDP1 | |
| SCHEMBL182548 | 0.68 | MAPT (0.47) | MEN1BLMKMT2A | |
| SCHEMBL29548300 | 0.68 | LMNA (0.47) | MEN1BLMKMT2ATDP1 | |
| SCHEMBL1133597 | 0.68 | TDP1 (0.37) | S100A4CDC25BTDP2NSD2PAX8 | |
| SCHEMBL8705259 | 0.68 | S100A4 (0.38) | S100A4CDC25BTDP2NSD2PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250221294-A1 | POLYMER, ORGANIC SEMICONDUCTOR MATERIAL, STRETCHABLE POLYMER THIN FILM, AND ELECTRONIC DEVICE | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2025-07-03 | — | — | US | disclosed |
| CN-119604539-A | Antigen binding molecules with increased brain penetration and retention and methods of use thereof | 中外制药株式会社 | 2025-03-11 | — | — | CN | disclosed |
| WO-2025036442-A1 | METHOD FOR PREPARING PYRAZINONAPHTHYRIDINE DIONE COMPOUND, AND INTERMEDIATE THEREOF | 劲方医药科技(上海)股份有限公司 | 2025-02-20 | — | — | WO | disclosed |
| CN-118871462-A | Anti-interleukin-33 antibodies and uses thereof | 基因泰克公司 | 2024-10-29 | — | — | CN | disclosed |
| CN-118401546-A | Stabilized IL-18 polypeptides and uses thereof | 基因泰克公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-118369349-A | Antibodies that bind to CD3 and PLAP | 豪夫迈·罗氏有限公司 | 2024-07-19 | — | — | CN | disclosed |
| CN-118271445-A | Antibodies that bind to CD3 | 豪夫迈·罗氏有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-113621062-B | Antibodies that bind to CD3 | 豪夫迈·罗氏有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-113195056-B | Antibodies that bind to CD3 | 豪夫迈·罗氏有限公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-111212850-B | Copy protection for antibodies | 豪夫迈·罗氏有限公司 | 2024-04-16 | — | — | CN | disclosed |
| US-20150344476-A1 | Naphthyridinedione derivatives | NOVARTIS AG (CH) | 2015-12-03 | — | — | US | disclosed |
| US-20150218164-A1 | SUBSTITUTED NAPHTHYRIDINEDIONE DERIVATIVES AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2015-08-06 | — | — | US | disclosed |
| US-20150218164-A1 | SUBSTITUTED NAPHTHYRIDINEDIONE DERIVATIVES AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2015-08-06 | — | — | US | disclosed |
| US-9073920-B2 | Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor | PURDUE RESEARCH FOUNDATION (US) | 2015-07-07 | — | — | US | disclosed |
| EP-2877469-A1 | SUBSTITUTED NAPHTHYRIDINEDIONE DERIVATIVES AS HIV INTEGRASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-06-03 | — | — | EP | disclosed |
| EP-2877469-A1 | SUBSTITUTED NAPHTHYRIDINEDIONE DERIVATIVES AS HIV INTEGRASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-06-03 | — | — | EP | disclosed |
| WO-2014018449-A1 | SUBSTITUTED NAPHTHYRIDINEDIONE DERIVATIVES AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-01-30 | — | — | WO | disclosed |
| WO-2014018449-A1 | SUBSTITUTED NAPHTHYRIDINEDIONE DERIVATIVES AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-01-30 | — | — | WO | disclosed |
| US-20130143878-A1 | SUBSTITUTED DIBENZONAPHTHYRIDINES, PHARMACEUTICAL USES THEREOF AND PROCESSES THERFOR | PURDUE RESEARCH FOUNDATION (US) | 2013-06-06 | — | — | US | disclosed |
| WO-2012024437-A1 | SUBSTITUTED DIBENZONAPHTHYRIDINES, PHARMACEUTICAL USES THEREOF AND PROCESSES THERFOR | PURDUE RESEARCH FOUNDATION (US) | 2012-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143878-A1 | SUBSTITUTED DIBENZONAPHTHYRIDINES, PHARMACEUTICAL USES THEREOF AND PROCESSES THERFOR | KRAS, QDPR, BTD | BRD4 289/4885S100A4 3031/4885CDC25B 3955/4885 |
| US-20150218164-A1 | SUBSTITUTED NAPHTHYRIDINEDIONE DERIVATIVES AS HIV INTEGRASE INHIBITORS | SAMHD1, ENTPD5, DUT | BRD4 390/4885S100A4 4750/4885CDC25B 583/4885 |
| US-20150344476-A1 | Naphthyridinedione derivatives | NPM1, CYP2D6, NQO1 | BRD4 458/4885S100A4 1601/4885CDC25B 1348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.