SCHEMBL6709221

SCHEMBL6709221

O=C(Nc1ccc(Br)cc1-c1nnn[nH]1)c1cc2ccc(Cl)cc2[nH]1

nearest known ligand 0.53

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 6/20 0.46
GPR35 Q9HC97 3/20 0.43
NHERF1 O14745 2/20 0.40
PYGL P06737 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6708921 0.93 ALOX15 (0.51) ALOX15NHERF1PYGL
SCHEMBL6709900 0.87 NPC1 (0.47) GPR35
SCHEMBL6711679 0.86 GPR35 (0.50) GPR35
SCHEMBL6708816 0.86 ALOX15 (0.44) ALOX15NHERF1PYGL
SCHEMBL6711642 0.85 NHERF1 (0.49) NHERF1PYGL
SCHEMBL6712151 0.84 FLT3 (0.48) ALOX15
SCHEMBL6707909 0.82 MAP3K5 (0.41) ALOX15GPR35PYGL
SCHEMBL6711843 0.82 GRIK1 (0.51) ALOX15GPR35NHERF1PYGL
SCHEMBL6711486 0.81 NPC1 (0.42)
SCHEMBL6709194 0.81 FLT3 (0.45) GPR35

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040142981-A1 Antibacterial benzoic acid derivatives PHARMACIA & UPJOHN COMPANY 2004-07-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040142981-A1 Antibacterial benzoic acid derivatives GABRD, PHB1, GABBR1 ALOX15 857/4885GPR35 2928/4885NHERF1 1641/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.