Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8448356 | 1.00 | HRH3 (0.56) | HRH3ACHEMEN1KMT2AMAPT | |
| SCHEMBL6712162 | 0.95 | MAPT (0.54) | HRH3ACHEMEN1KMT2AMAPT | |
| SCHEMBL6605777 | 0.85 | ALDH1A1 (0.48) | HRH3ACHEMEN1KMT2AMAPT | |
| SCHEMBL6493247 | 0.85 | MAPT (0.56) | HRH3MEN1KMT2AMAPTSIRT6 | |
| SCHEMBL12803097 | 0.82 | ACHE (0.53) | HRH3ACHEMEN1KMT2AMAPT | |
| SCHEMBL12803100 | 0.82 | ACHE (0.53) | HRH3ACHEMEN1KMT2AMAPT | |
| SCHEMBL9984463 | 0.82 | MAPT (0.46) | HRH3ACHEMEN1KMT2AMAPT | |
| SCHEMBL15828757 | 0.80 | MAPT (0.49) | HRH3MEN1KMT2AMAPTSIRT6 | |
| SCHEMBL6712849 | 0.80 | MAPT (0.47) | HRH3ACHEMEN1KMT2AMAPT | |
| SCHEMBL13292851 | 0.80 | KMT2A (0.50) | HRH3MEN1KMT2AMAPTSIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040198731-A1 | Aminoalkyl-substituted aromatic bicyclic compounds, methods for their preparation and their use as pharmaceuticals | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-10-07 | — | — | US | disclosed |
| US-20040198732-A1 | Aminoalkyl-substituted aromatic bicyclic compounds, methods for their preparation and their use as pharmaceuticals | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-10-07 | — | — | US | disclosed |
| US-20040198733-A1 | Aminoalkyl-substituted aromatic bicyclic compounds, methods for their preparation and their use as pharmaceuticals | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-10-07 | — | — | US | disclosed |
| US-20040192693-A1 | Aminoalkyl-substituted aromatic bicyclic compounds, methods for their preparation and their use as pharmaceuticals | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-09-30 | — | — | US | disclosed |
| US-20040088799-A1 | Oxidation dyeing composition based on 1-(4-aminophenyl) pyrrolidines substituted in position 2 | L'OREAL S.A. (FR) | 2004-05-13 | — | — | US | disclosed |
| US-20030212070-A1 | Aminoalkyl-substituted aromatic bicyclic compounds, methods for their preparation and their use as pharmaceuticals | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-11-13 | — | — | US | disclosed |
| EP-1341509-A1 | OXIDATION DYEING COMPOSITION BASED ON 1-(4-AMINOPHENYL) PYRROLIDINES SUBSTITUTED IN POSITION 2 | L'OREAL (FR) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002045670-A1 | OXIDATION DYEING COMPOSITION BASED ON 1-(4-AMINOPHENYL) PYRROLIDINES SUBSTITUTED IN POSITION 2 | L'OREAL (FR) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040088799-A1 | Oxidation dyeing composition based on 1-(4-aminophenyl) pyrrolidines substituted in position 2 | PYCR1, COX5A, COX5B | HRH3 1675/4885ACHE 3972/4885MEN1 4624/4885 |
| US-20030212070-A1 | Aminoalkyl-substituted aromatic bicyclic compounds, methods for their preparation and their use as pharmaceuticals | PER2, CNR2, DDC | HRH3 615/4885ACHE 274/4885MEN1 3604/4885 |
| US-20040192693-A1 | Aminoalkyl-substituted aromatic bicyclic compounds, methods for their preparation and their use as pharmaceuticals | PER2, CNR2, DDC | HRH3 615/4885ACHE 274/4885MEN1 3604/4885 |
| US-20040198731-A1 | Aminoalkyl-substituted aromatic bicyclic compounds, methods for their preparation and their use as pharmaceuticals | PER2, CNR2, DDC | HRH3 615/4885ACHE 274/4885MEN1 3604/4885 |
| US-20040198733-A1 | Aminoalkyl-substituted aromatic bicyclic compounds, methods for their preparation and their use as pharmaceuticals | PER2, CNR2, DDC | HRH3 615/4885ACHE 274/4885MEN1 3604/4885 |
| US-20040198732-A1 | Aminoalkyl-substituted aromatic bicyclic compounds, methods for their preparation and their use as pharmaceuticals | PER2, CNR2, DDC | HRH3 615/4885ACHE 274/4885MEN1 3604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.