SCHEMBL6725936

SCHEMBL6725936

O=C(COc1c(I)cc(S(=O)(=O)c2cc(I)c(O)c(I)c2)cc1I)Oc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.40
ALDH1A1 P00352 5/20 0.39
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
HPGD P15428 2/20 0.39
MAPT P10636 2/20 0.38
KDM4E B2RXH2 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
NPSR1 Q6W5P4 1/20 0.37
THRB P10828 5/20 0.36
THRA P10827 4/20 0.36
RXRA P19793 2/20 0.36
PPARG P37231 2/20 0.36
ITGB3 P05106 1/20 0.36
ITGAV P06756 1/20 0.36
LMNA P02545 3/20 0.36
TTR P02766 2/20 0.36
ADORA3 P0DMS8 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6728507 0.85 MEN1 (0.49) GAAALDH1A1MEN1KMT2AHPGD
SCHEMBL6820149 0.85 MEN1 (0.43) GAAALDH1A1MEN1KMT2AHPGD
SCHEMBL6725854 0.83 LMNA (0.42) GAAALDH1A1MEN1KMT2AHPGD
SCHEMBL6725083 0.72 ESR1 (0.49) ALDH1A1MEN1KMT2AHPGDNPC1
SCHEMBL6723683 0.71 TPMT (0.47) GAAALDH1A1MEN1KMT2AMAPT
SCHEMBL6721262 0.69 IDO1 (0.42) HPGDLMNA
SCHEMBL472034 0.69 ALOX15 (0.65) GAAALDH1A1MEN1KMT2AHPGD
SCHEMBL6723591 0.68 THRA (0.46) ALDH1A1KMT2AHPGDKDM4ENPC1
SCHEMBL6721180 0.68 ALDH1A1 (0.43) ALDH1A1MEN1KMT2AHPGDKDM4E
SCHEMBL8864820 0.67 ALDH1A1 (0.50) GAAALDH1A1MEN1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1044824-B1 Bis(arylsulfonylaminocarbonylaminobenzoate) compounds and thermosensitive recording materials containing same OJI PAPER CO (JP) 2004-05-12 EP disclosed
US-6677472-B2 AS COLOR-DEVELOPING AGENT; HIGH WHITENESS AND RESISTANCE TO COLOR FORMATION UNDER HIGH TEMPERATURE OJI PAPER CO., LTD. (JP) 2004-01-13 US disclosed
US-6677473-B1 TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER CORVAS INTERNATIONAL INC 2004-01-13 US disclosed
US-6486094-B1 Bis (arylsulfonylaminocarbonylaminobenzoate) compounds and thermosensitive recording materials containing same OJI PAPER CO., LTD. (JP) 2002-11-26 US disclosed
US-20020065196-A1 Bis (arylsulfonylaminocarbonylaminobenzoate) compounds and thermosensitive recording materials containing same OJI PAPER CO., LTD. (JP) 2002-05-30 US disclosed
WO-2001036351-A2 PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS CORVAS INTERNATIONAL, INC. (US) 2001-05-25 WO disclosed
EP-1044824-A2 Bis(arylsulfonylaminocarbonylaminobenzoate) compounds and thermosensitive recording materials containing same OJI PAPER COMPANY LIMITED (JP) 2000-10-18 EP disclosed