Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDHB | P21912 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | GALR1 | P47211 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746349 | 0.87 | PTGS2 (0.41) | PTGS2PTGS1CASP1 | |
| SCHEMBL6746288 | 0.87 | CASP1 (0.35) | PTGS2CASP1 | |
| SCHEMBL6745120 | 0.85 | ACLY (0.35) | SDHBPTGS2PTGS1NR1H2NR1H3 | |
| SCHEMBL6743237 | 0.85 | PTGS2 (0.38) | PTGS2PTGS1CASP1 | |
| SCHEMBL6746293 | 0.85 | PTGS2 (0.38) | PTGS2CASP1CA1CA2GALR1 | |
| SCHEMBL6746753 | 0.84 | PTGS2 (0.45) | SDHBPTGS2PTGS1CASP1 | |
| SCHEMBL6746730 | 0.83 | PTGS2 (0.38) | PTGS2AKR1C3AKR1C2CASP1 | |
| SCHEMBL6749791 | 0.83 | PTGS2 (0.40) | PTGS2AKR1C3AKR1C2CA1CA2 | |
| SCHEMBL6750004 | 0.82 | PTGS2 (0.46) | PTGS2PTGS1CASP1 | |
| SCHEMBL6747309 | 0.82 | PTGS2 (0.47) | PTGS2PTGS1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |