Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4237669 | 0.72 | CYP3A4 (0.32) | CYP3A4BLM | |
| SCHEMBL676634 | 0.72 | KDM4E (0.43) | CYP3A4BLM | |
| SCHEMBL11100644 | 0.69 | — | — | |
| SCHEMBL7077081 | 0.68 | KDM4E (0.33) | CYP3A4BLM | |
| SCHEMBL7362056 | 0.68 | KDM4E (0.33) | CYP3A4BLM | |
| SCHEMBL24149523 | 0.67 | CYP1A2 (0.33) | CYP3A4BLM | |
| SCHEMBL4237665 | 0.66 | NOS1 (0.38) | — | |
| SCHEMBL851106 | 0.65 | KDM4E (0.32) | CYP3A4BLM | |
| SCHEMBL3454166 | 0.63 | PNP (0.32) | CYP3A4BLM | |
| SCHEMBL9152040 | 0.63 | DHFR (0.40) | CYP3A4BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138142-A1 | COMPOSITIONS AND USE OF SULFASALAZINE | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2011-11-10 | — | — | WO | claimed |
| EP-1696877-A2 | METHODS FOR TREATING PAIN | THE GENERAL HOSPITAL CORPORATION (US) | 2006-09-06 | — | — | EP | claimed |
| US-20050197341-A1 | Methods for treating pain | GENERAL HOSPITAL CORPORATION, THE | 2005-09-08 | — | — | US | claimed |
| WO-2005048926-A2 | METHODS FOR TREATING PAIN | THE GENERAL HOSPITAL CORPORATION (US) | 2005-06-02 | — | — | WO | claimed |
| US-12421187-B2 | Dihydrofolate synthase (DHFS) inhibiting agents and methods of making and using same | WASHINGTON UNIVERISTY (US) | 2025-09-23 | — | — | US | disclosed |
| WO-2024022365-A1 | WNT PATHWAY INHIBITOR COMPOUND | 杭州阿诺生物医药科技有限公司 | 2024-02-01 | — | — | WO | disclosed |
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | WASHINGTON UNIVERSITY (US) | 2023-10-12 | — | — | US | disclosed |
| WO-2022214053-A1 | UBIQUITIN-SPECIFIC PROTEASE 1 (USP1) INHIBITOR | 海南耀臻生物医药科技有限公司 | 2022-10-13 | — | — | WO | disclosed |
| EP-4029519-A1 | TETRAHYDROBIOPTERIN FOR TREATING CONDITIONS ASSOCIATED WITH ELEVATED PHENYLALANINE LEVELS | BioMarin Pharmaceutical Inc. (US) | 2022-07-20 | — | — | EP | disclosed |
| EP-3461503-B9 | METHODS OF ADMINISTERING TETRAHYDROBIOPTERIN, ASSOCIATED COMPOSITIONS, AND METHODS OF MEASURING | BIOMARIN PHARM INC (US) | 2022-05-11 | — | — | EP | disclosed |
| EP-3461503-B1 | METHODS OF ADMINISTERING TETRAHYDROBIOPTERIN, ASSOCIATED COMPOSITIONS, AND METHODS OF MEASURING | BIOMARIN PHARM INC (US) | 2022-02-09 | — | — | EP | disclosed |
| EP-2545939-B1 | Tetrahydrobiopterin for treating conditions associated with elevated phenylalanine levels | BIOMARIN PHARM INC (US) | 2020-12-16 | — | — | EP | disclosed |
| EP-0138995-B1 | REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES | South Alabama Medical Science Foundation (US) | 1991-08-14 | — | — | EP | disclosed |
| EP-0138995-A4 | REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES. | UNIV SOUTH ALABAMA (US) | 1988-05-10 | — | — | EP | disclosed |
| US-4701455-A | NERVOUS SYSTEM DISORDERS, PARKINSON'S DISEASE | BURROUGHS WELLCOME CO. (US) | 1987-10-20 | — | — | US | disclosed |
| US-4587340-A | ANTIDEPRESSANTS | BURROUGHS WELLCOME CO. (US) | 1986-05-06 | — | — | US | disclosed |
| EP-0138995-A1 | REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES. | UNIV SOUTH ALABAMA (US) | 1985-05-02 | — | — | EP | disclosed |
| WO-1984004040-A1 | REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES | UNIV SOUTH ALABAMA (US) | 1984-10-25 | — | — | WO | disclosed |
| EP-0012444-B1 | DIAGNOSTIC METHOD, ESPECIALLY FOR THE EARLY RECOGNITION OF MALIGNANT TUMORS AND/OR VIRAL DISEASES, AND MEANS TO CARRY IT OUT | Wachter, Helmut, Univ.-Prof. Dr. (AT) | 1984-07-25 | — | — | EP | disclosed |
| EP-0012444-A1 | Diagnostic method, especially for the early recognition of malignant tumors and/or viral diseases, and means to carry it out | Wachter, Helmut, Univ.-Prof. Dr. (AT) | 1980-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | DHFR, DHPS, MTHFD1 | CYP3A4 2111/4885BLM 1822/4885 |
| US-20050197341-A1 | Methods for treating pain | SPR, QDPR, SHMT1 | CYP3A4 220/4885BLM 4585/4885 |
| US-12421187-B2 | Dihydrofolate synthase (DHFS) inhibiting agents and methods of making and using same | DHFR, DHPS, MTHFD1 | CYP3A4 2111/4885BLM 1822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.