Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.31 |
| ▸ | ARG1 | P05089 | 2/20 | 0.31 |
| ▸ | ARG2 | P78540 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8361776 | 0.92 | SIGMAR1 (0.46) | SIGMAR1CACNA2D1SLC2A1NPSR1CHRM2 | |
| SCHEMBL17523762 | 0.90 | SIGMAR1 (0.44) | SIGMAR1CACNA2D1SLC6A2SLC6A4KCNH2 | |
| SCHEMBL17523776 | 0.90 | SIGMAR1 (0.44) | SIGMAR1CACNA2D1SLC6A2SLC6A4KCNH2 | |
| SCHEMBL21016075 | 0.90 | SIGMAR1 (0.44) | SIGMAR1CACNA2D1SLC6A2SLC6A4KCNH2 | |
| SCHEMBL14731785 | 0.90 | SIGMAR1 (0.44) | SIGMAR1CACNA2D1SLC6A2SLC6A4KCNH2 | |
| SCHEMBL10225595 | 0.87 | KCNH2 (0.33) | SIGMAR1CACNA2D1CHRM2HTR1AADRA2A | |
| SCHEMBL15183480 | 0.87 | CACNA2D1 (0.32) | SIGMAR1CACNA2D1 | |
| SCHEMBL13044264 | 0.85 | — | — | |
| SCHEMBL26455606 | 0.84 | SIGMAR1 (0.40) | SIGMAR1CHRM2HTR1AADRA2ACHRM1 | |
| SCHEMBL841265 | 0.82 | TSHR (0.33) | SIGMAR1ARG1ARG2TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11833122-B2 | Aminonaphthoquinone compounds for treatment and/or prevention of fibrosis diseases | CALGENT BIOTECHNOLOGY CO., LTD. (TW) | 2023-12-05 | — | — | US | disclosed |
| US-20220396548-A1 | IONIZABLE LIPIDS FOR NUCLEIC ACID DELIVERY | GLOBAL LIFE SCIENCES SOLUTIONS CANADA ULC (CA) | 2022-12-15 | — | — | US | disclosed |
| WO-2022170834-A1 | USE OF IONIZABLE CATIONIC LIPID ANALOG MATERIAL AS PROTEIN DRUG DELIVERY CARRIER | 中山大学 | 2022-08-18 | — | — | WO | disclosed |
| US-11013696-B2 | Lipids and lipid compositions for the delivery of active agents | NOVARTIS AG (CH) | 2021-05-25 | — | — | US | disclosed |
| US-10844002-B2 | Lipids and lipid compositions for the delivery of active agents | NOVARTIS AG (CH) | 2020-11-24 | — | — | US | disclosed |
| US-20200172538-A1 | COMPOUNDS FOR BONE GROWTH | OSSIFI THERAPEUTICS LLC | 2020-06-04 | — | — | US | disclosed |
| US-10647747-B2 | Cyclosporin derivatives and uses thereof | S&T GLOBAL INC. (US) | 2020-05-12 | — | — | US | disclosed |
| US-20190151403-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T GLOBAL INC. | 2019-05-23 | — | — | US | disclosed |
| US-20190002393-A1 | Lipids and Lipid Compositions for the Delivery of Active Agents | NOVARTIS AG (CH) | 2019-01-03 | — | — | US | disclosed |
| US-20180105558-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T GLOBAL INC. | 2018-04-19 | — | — | US | disclosed |
| US-20070149538-A1 | Diarylamine-Containing Compounds and Compositions, and their use as Modulators of C-Kit Receptors | IRM LLC (BM) | 2007-06-28 | — | — | US | disclosed |
| US-20070149538-A1 | Diarylamine-Containing Compounds and Compositions, and their use as Modulators of C-Kit Receptors | IRM LLC (BM) | 2007-06-28 | — | — | US | disclosed |
| US-20070105852-A1 | Thiophene and furan compounds | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| US-7205313-B2 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-04-17 | — | — | US | disclosed |
| US-20070066573-A1 | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2007-03-22 | — | — | US | disclosed |
| US-7157582-B2 | Selective iGluR5 receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-01-02 | — | — | US | disclosed |
| CN-1249068-C | Chemical products suitable as cocatalysts, their preparation and their use in catalyst systems for the preparation of polyolefins | BASELL POLYOLEFINE GMBH (DE) | 2006-04-05 | — | — | CN | disclosed |
| CN-1433339-A | New catalyst system and application thereof | BASELL POLYROPYLEN GMBH (DE) | 2003-07-30 | — | — | CN | disclosed |
| CN-1427842-A | Chemical products suited for use as co-catalysts, method for preparation thereof and their use in catalyst systems for producing polyolefins | BASELL POLYOLEFINE GMBH (DE) | 2003-07-02 | — | — | CN | disclosed |
| US-4543411-A | RUTHENIUM CONTAINING CATALYST MIXED WITH PHOSPHONIUM SALT | TEXACO INC. (US) | 1985-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10844002-B2 | Lipids and lipid compositions for the delivery of active agents | LRAT, LIPA, LPAR1 | SIGMAR1 1374/4885CACNA2D1 3778/4885SLC2A1 424/4885 |
| US-20220396548-A1 | IONIZABLE LIPIDS FOR NUCLEIC ACID DELIVERY | RNASEH1, NSUN3, SLC67A1 | SIGMAR1 1423/4885CACNA2D1 3650/4885SLC2A1 888/4885 |
| US-20190151403-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | MALT1, MYLK2, FKBP1B | SIGMAR1 2494/4885CACNA2D1 1080/4885SLC2A1 802/4885 |
| US-20200172538-A1 | COMPOUNDS FOR BONE GROWTH | FGF1, FGF2, BMP2 | SIGMAR1 4835/4885CACNA2D1 1540/4885SLC2A1 376/4885 |
| US-10647747-B2 | Cyclosporin derivatives and uses thereof | FKBP5, FKBP1B, MALT1 | SIGMAR1 4049/4885CACNA2D1 2176/4885SLC2A1 1296/4885 |
| US-11013696-B2 | Lipids and lipid compositions for the delivery of active agents | PHOSPHO1, SGMS1, LIPA | SIGMAR1 628/4885CACNA2D1 2860/4885SLC2A1 732/4885 |
| US-11833122-B2 | Aminonaphthoquinone compounds for treatment and/or prevention of fibrosis diseases | KEAP1, GOT2, COL1A1 | SIGMAR1 4602/4885CACNA2D1 4743/4885SLC2A1 2941/4885 |
| US-20070149538-A1 | Diarylamine-Containing Compounds and Compositions, and their use as Modulators of C-Kit Receptors | KIT, PRKCH, PRKCE | SIGMAR1 1250/4885CACNA2D1 453/4885SLC2A1 3337/4885 |
| US-20070105852-A1 | Thiophene and furan compounds | PSEN2, PSEN1, TPMT | SIGMAR1 1229/4885CACNA2D1 1556/4885SLC2A1 1453/4885 |
| US-20070066573-A1 | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors | GRIN1, GRIN3A, GRIK5 | SIGMAR1 633/4885CACNA2D1 124/4885SLC2A1 2363/4885 |
| US-20190002393-A1 | Lipids and Lipid Compositions for the Delivery of Active Agents | LRAT, LIPA, LPAR1 | SIGMAR1 1374/4885CACNA2D1 3778/4885SLC2A1 424/4885 |
| US-20180105558-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | FKBP1B, MALT1, FKBP5 | SIGMAR1 3999/4885CACNA2D1 1843/4885SLC2A1 1138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.