Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6801133 | 0.78 | LMNA (0.35) | PPARDSMN1; SMN2L3MBTL1KMT2AFFAR1 | |
| SCHEMBL7253305 | 0.75 | RAB9A (0.40) | ADAM17ATAD2MMP2MMP9PPARD | |
| SCHEMBL6803571 | 0.74 | RAB9A (0.40) | RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6806039 | 0.72 | MAPT (0.41) | RAB9ANPC1SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL910584 | 0.71 | NQO1 (0.58) | RAB9ANPC1SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL6804638 | 0.71 | GRM5 (0.41) | RAB9ANPC1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL6804907 | 0.71 | MAOB (0.41) | ADAM17RAB9ANPC1ALDH1A1 | |
| SCHEMBL6804943 | 0.70 | FFAR1 (0.49) | ADAM17FFAR1 | |
| SCHEMBL6804913 | 0.70 | PARP10 (0.56) | SMN1; SMN2MAPK1FFAR1MAPTALDH1A1 | |
| SCHEMBL6804893 | 0.70 | SOD1 (0.42) | RAB9ANPC1SMN1; SMN2L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |
| WO-2003016248-A2 | BICYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$G(A) CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY PATENT DEPARTMENT (US) | 2003-02-27 | — | — | WO | disclosed |