SCHEMBL6809866

SCHEMBL6809866

O=C1C=C(CCc2ccc(O)cc2)C(=O)N1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 4/20 0.50
ESR2 Q92731 2/20 0.50
LTA4H P09960 1/20 0.42
CA2 P00918 1/20 0.41
KDM4E B2RXH2 3/20 0.39
ALDH1A1 P00352 3/20 0.39
ADRA2A P08913 3/20 0.39
SLC6A2 P23975 3/20 0.39
HTR1A P08908 1/20 0.39
CYP2C19 P33261 1/20 0.39
HTR3A P46098 1/20 0.39
BACE1 P56817 1/20 0.39
TAAR1 Q96RJ0 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
NR1H3 Q13133 1/20 0.39
BLM P54132 1/20 0.38
KMT2A Q03164 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
DAO P14920 1/20 0.37
TMEM97 Q5BJF2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4804512 0.84 ESR1 (0.46) ESR1ESR2CA2KDM4EALDH1A1
SCHEMBL3825008 0.81 PARK7 (0.47) ALDH1A1KMT2ADAOHSD17B10
SCHEMBL1398019 0.80 GSK3A (0.32)
Water SCHEMBL28158179 0.78 GSK3A (0.30)
SCHEMBL6941834 0.77 LMNA (0.41) ESR1KDM4ESLC6A2KMT2AHSD17B10
SCHEMBL1316857 0.76 MAOA (0.39) NR1H3KMT2ADAO
SCHEMBL29800250 0.73 RAB9A (0.44) ESR1ESR2LTA4HCA2KDM4E
SCHEMBL331188 0.72
SCHEMBL9508340 0.72 MAOA (0.35) L3MBTL1KMT2A
SCHEMBL548121 0.72 STAT3 (0.35) BACE1ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250215093-A1 FUSION PROTEIN COMPRISING AN EGFR-BINDING DOMAIN AND A MASKING DOMAIN ZYTOX THERAPEUTICS AB (SE) 2025-07-03 US disclosed
EP-4473014-A1 FUSION PROTEIN COMPRISING AN EGFR-BINDING DOMAIN AND A MASKING DOMAIN Zytox Therapeutics AB (SE) 2024-12-11 EP disclosed
CN-118647632-A Fusion proteins comprising EGFR binding and masking domains 齐托克斯治疗公司 2024-09-13 CN disclosed
US-20230250160-A1 BISPECIFIC PROTEIN HOBER BIOTECH AB (SE) 2023-08-10 US disclosed
WO-2023148388-A1 FUSION PROTEIN COMPRISING AN EGFR-BINDING DOMAIN AND A MASKING DOMAIN ZYTOX THERAPEUTICS AB (SE) 2023-08-10 WO disclosed
US-20230107890-A1 THERAPEUTIC AGENT TARGETING HER2 HOBER BIOTECH AB (SE) 2023-04-06 US disclosed
EP-4143223-A1 BISPECIFIC PROTEIN Hober Biotech AB (SE) 2023-03-08 EP disclosed
CN-115698056-A Bispecific proteins 霍伯生物技术公司 2023-02-03 CN disclosed
EP-4117786-A1 THERAPEUTIC AGENT TARGETING HER2 Hober Biotech AB (SE) 2023-01-18 EP disclosed
CN-115397516-A Therapeutic agents targeting HER2 霍伯生物技术公司 2022-11-25 CN disclosed
WO-2021219818-A1 BISPECIFIC PROTEIN HOBER BIOTECH AB (SE) 2021-11-04 WO disclosed
EP-3904378-A1 BISPECIFIC PROTEIN Hober Biotech AB (SE) 2021-11-03 EP disclosed
WO-2021180727-A1 THERAPEUTIC AGENT TARGETING HER2 HOBER BIOTECH AB (SE) 2021-09-16 WO disclosed
EP-3878515-A1 THERAPEUTIC AGENT TARGETING HER2 Hober Biotech AB (SE) 2021-09-15 EP disclosed
US-20040038876-A1 Polymer conjugates of hedgehog proteins and uses CURIS, INC. 2004-02-26 US disclosed
EP-1203141-A1 LINKAGE OF AGENTS TO TISSUE Pericor Science, Inc. (US) 2002-05-08 EP disclosed
EP-1183271-A1 POLYMER CONJUGATES OF HEDGEHOG PROTEINS AND USES BIOGEN, INC. (US) 2002-03-06 EP disclosed
WO-2000073337-A9 POLYMER CONJUGATES OF HEDGEHOG PROTEINS AND USES BIOGEN INC (US) 2002-02-14 WO disclosed
WO-2001006829-A2 LINKAGE OF AGENTS TO TISSUE PERICOR SCIENCE, INC. (US) 2001-02-01 WO disclosed
WO-2000073337-A1 POLYMER CONJUGATES OF HEDGEHOG PROTEINS AND USES BIOGEN, INC. (US) 2000-12-07 WO disclosed