Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27576496 | 0.83 | KMO (0.47) | KMOCA12CA1CA2CA6 | |
| Biphenyl SCHEMBL27587719 | 0.81 | HSD17B1 (0.36) | AKR1C3ALDH1A1TSHRCYP2C9PARP1 | |
| SCHEMBL6820924 | 0.80 | AKR1B1 (0.41) | LMNATSHRCYP1A2HPGDPRSS1 | |
| SCHEMBL6812678 | 0.79 | MRGPRX4 (0.42) | KMOCA12CA1CA2CA6 | |
| SCHEMBL27558267 | 0.78 | EGFR (0.37) | CA12CA1CA2CA6CA9 | |
| SCHEMBL6920197 | 0.77 | ALDH1A1 (0.41) | CA12CA1CA2CA6CA9 | |
| SCHEMBL27587710 | 0.77 | HSD17B1 (0.41) | AKR1C3CYP2C9 | |
| SCHEMBL5210586 | 0.76 | HTR1F (0.43) | — | |
| SCHEMBL5612906 | 0.76 | TTR (0.40) | CA12CA1CA2CA6CA9 | |
| SCHEMBL7741614 | 0.74 | NR4A2 (0.40) | CA12CA1CA2CA6CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185271-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-04 | — | — | EP | disclosed |
| CN-1356902-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 2002-07-03 | — | — | CN | disclosed |
| EP-1185271-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076515-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |