Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6816973 | 0.77 | KMO (0.39) | ALDH1A1LMNACA12CA1CA2 | |
| SCHEMBL6820717 | 0.77 | ALDH1A1 (0.51) | ALDH1A1TP53MAPTKDM4EPOLB | |
| SCHEMBL27576157 | 0.73 | HNF4A (0.54) | ALDH1A1MAPTKMT2ALMNAPTPN1 | |
| SCHEMBL27519456 | 0.72 | MMP2 (0.44) | ALDH1A1KDM4EKMT2ACA12CA1 | |
| Biphenyl SCHEMBL27587719 | 0.72 | HSD17B1 (0.36) | ALDH1A1NPC1RAB9APTPN1 | |
| SCHEMBL7611518 | 0.72 | AKR1C3 (0.46) | ALDH1A1KDM4EGLAPTPN1 | |
| SCHEMBL27587734 | 0.71 | CXCR2 (0.45) | KMT2AHPGDHSD17B10 | |
| SCHEMBL6820924 | 0.71 | AKR1B1 (0.41) | POLBLMNAGAAHPGDHTT | |
| SCHEMBL27519344 | 0.71 | CXCR2 (0.37) | ALDH1A1TDP1 | |
| SCHEMBL5950300 | 0.70 | ALDH1A1 (0.50) | ALDH1A1TP53KDM4ERAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185271-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-04 | — | — | EP | disclosed |
| CN-1356902-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 2002-07-03 | — | — | CN | disclosed |
| EP-1185271-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076515-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |