Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 2/20 | 0.75 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18087850 | 0.94 | AGTR2 (0.75) | AGTR2ABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL19133020 | 0.94 | AGTR2 (0.75) | AGTR2ABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL28653349 | 0.93 | AGTR2 (0.82) | AGTR2ABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL30206762 | 0.93 | AGTR2 (0.82) | AGTR2ABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL30539216 | 0.93 | AGTR2 (0.82) | AGTR2ABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL18087851 | 0.92 | AGTR2 (0.72) | AGTR2ABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL18087855 | 0.91 | AGTR2 (0.70) | AGTR2ABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL965217 | 0.90 | AGTR2 (0.75) | AGTR2ABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL13281316 | 0.89 | AGTR2 (0.74) | AGTR2ABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL7017897 | 0.89 | AGTR2 (0.59) | AGTR2ABCB11EGFRERBB2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119715-B1 | Benzimidazole derivative and its use as AII receptor antagonist | TAKEDA PHARMACEUTICAL (JP) | 2012-05-30 | — | — | EP | disclosed |
| US-20110269717-A1 | NEUROGENESIS BY MODULATING ANGIOTENSIN | BRAINCELLS INC. (US) | 2011-11-03 | — | — | US | disclosed |
| US-20110269717-A1 | NEUROGENESIS BY MODULATING ANGIOTENSIN | BRAINCELLS INC. (US) | 2011-11-03 | — | — | US | disclosed |
| US-20110046090-A1 | MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS | BRAINCELLS INC. (US) | 2011-02-24 | — | — | US | disclosed |
| US-20110046090-A1 | MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS | BRAINCELLS INC. (US) | 2011-02-24 | — | — | US | disclosed |
| US-7875637-B2 | improving insulin resistance with azilsartan medoxomil, aka (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate; combination therapy with other antidiabetic agents | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-01-25 | — | — | US | disclosed |
| EP-2119715-A1 | Benzimidazole derivative and its use as aii receptor antagonist | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| US-20090270464-A1 | Benzimidazole derivative and use as a II receptor antagonist | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2009-10-29 | — | — | US | disclosed |
| US-7572920-B2 | Benzimidazole derivative and use as a II receptor antagonist | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-08-11 | — | — | US | disclosed |
| EP-1718641-B1 | BENZIMIDAZOLE DERIVATIVE AND ITS USE AS A II RECEPTOR ANTAGONIST | TAKEDA PHARMACEUTICAL (JP) | 2007-08-15 | — | — | EP | disclosed |
| US-7157584-B2 | Benzimidazole derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-02 | — | — | US | disclosed |
| US-20060281795-A1 | Benzinidazole Derivative and Use As AII Receptor Antagonist | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-12-14 | — | — | US | disclosed |
| EP-1718641-A2 | BENZIMIDAZOLE DERIVATIVE AND ITS USE AS AII RECEPTOR ANTAGONIST | Takeda Pharmaceutical Company Limited (JP) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005080384-A2 | BENZIMIDAZOLE DERIVATIVE AND USE AS AII RECEPTOR ANTAGONIST | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-09-01 | — | — | WO | disclosed |
| US-20050187269-A1 | Benzimidazole derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046090-A1 | MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS | GAP43, GABRB1, GABRB3 | AGTR2 2610/4885ABCB11 4659/4885EGFR 2001/4885 |
| US-20110269717-A1 | NEUROGENESIS BY MODULATING ANGIOTENSIN | NGF, DCX, BDNF | AGTR2 9/4885ABCB11 4566/4885EGFR 879/4885 |
| US-20060281795-A1 | Benzinidazole Derivative and Use As AII Receptor Antagonist | AGTR1, AGTR2, GPR119 | AGTR2 2/4885ABCB11 435/4885EGFR 1390/4885 |
| US-20050187269-A1 | Benzimidazole derivative and use thereof | REN, H1-3, GPR119 | AGTR2 40/4885ABCB11 158/4885EGFR 2761/4885 |
| US-20090270464-A1 | Benzimidazole derivative and use as a II receptor antagonist | AGTR1, BDKRB1, GPR119 | AGTR2 6/4885ABCB11 525/4885EGFR 572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.