Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116401 | 0.92 | — | — | |
| SCHEMBL8588523 | 0.89 | CYP2A6 (0.47) | LMNAALDH1A1CYP2A6MAOASLC6A4 | |
| SCHEMBL10528160 | 0.86 | ALDH1A1 (0.50) | ALDH1A1PTGS2HAO1NISCHMAOA | |
| SCHEMBL10300271 | 0.86 | ALDH1A1 (0.50) | ALDH1A1PTGS2HAO1NISCHMAOA | |
| SCHEMBL3954756 | 0.78 | CYP1A1 (0.59) | ALDH1A1 | |
| SCHEMBL3954754 | 0.78 | CYP1A1 (0.59) | ALDH1A1 | |
| SCHEMBL22167328 | 0.78 | SLC6A4 (0.54) | LMNAALDH1A1CYP2A6PTGS2MAOA | |
| SCHEMBL970462 | 0.78 | ALDH1A1 (0.48) | LMNAALDH1A1MAPK1PTGS2 | |
| SCHEMBL943735 | 0.78 | ALDH1A1 (0.52) | ALDH1A1MAPK1CYP2A6HAO1MAOA | |
| SCHEMBL8588228 | 0.78 | MAOA (0.56) | LMNAALDH1A1MAPK1CYP2A6HAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12371400-B2 | Cathepsin inhibitors | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2025-07-29 | — | — | US | disclosed |
| US-20240182409-A1 | CATHEPSIN INHIBITORS | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2024-06-06 | — | — | US | disclosed |
| US-11820734-B2 | Cathepsin inhibitors | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2023-11-21 | — | — | US | disclosed |
| EP-4046987-A1 | CATHEPSIN INHIBITORS | Academisch Ziekenhuis Leiden (h.o.d.n. LUMC) (NL) | 2022-08-24 | — | — | EP | disclosed |
| US-20220227705-A1 | CATHEPSIN INHIBITORS | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2022-07-21 | — | — | US | disclosed |
| EP-3720840-B1 | CATHEPSIN INHIBITORS | ACADEMISCH ZIEKENHUIS LEIDEN (NL) | 2022-01-19 | — | — | EP | disclosed |
| US-11174224-B2 | Cathepsin inhibitors | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2021-11-16 | — | — | US | disclosed |
| US-11174224-B2 | Cathepsin inhibitors | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2021-11-16 | — | — | US | disclosed |
| CN-108912020-B | Preparation method of Orobactit and intermediate thereof | 上海博志研新药物技术有限公司 | 2021-05-28 | — | — | CN | disclosed |
| WO-2020257487-A1 | GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE | BIOMARIN PHARMACEUTICAL INC. (US) | 2020-12-24 | — | — | WO | disclosed |
| US-20200385341-A1 | CATHEPSIN INHIBITORS | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2020-12-10 | — | — | US | disclosed |
| US-20200385341-A1 | CATHEPSIN INHIBITORS | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2020-12-10 | — | — | US | disclosed |
| EP-3720840-A1 | CATHEPSIN INHIBITORS | Academisch Ziekenhuis Leiden h.o.d.n. LUMC (NL) | 2020-10-14 | — | — | EP | disclosed |
| WO-2019112426-A1 | CATHEPSIN INHIBITORS | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2019-06-13 | — | — | WO | disclosed |
| WO-2013002514-A2 | ORGANIC ELECTROLUMINESCENCE DEVICE USING DIARYLAMINE DERIVATIVES, AND NOVEL COMPOUND AND COMPOSITION FOR ORGANIC ELECTROLUMINESCENCE DEVICE | 덕산하이메탈(주) (KR) | 2013-01-03 | — | — | WO | disclosed |
| US-20040266826-A1 | Thiophenylthiopyrane dioxides as mmp or tnf-alpha inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11820734-B2 | Cathepsin inhibitors | CTSK, CTSZ, CTSF | LMNA 2792/4885ALDH1A1 3238/4885MAPK1 3538/4885 |
| US-20040266826-A1 | Thiophenylthiopyrane dioxides as mmp or tnf-alpha inhibitors | TNF, MMP9, MMP1 | LMNA 2725/4885ALDH1A1 440/4885MAPK1 267/4885 |
| US-12371400-B2 | Cathepsin inhibitors | CTSK, CTSZ, CTSF | LMNA 2792/4885ALDH1A1 3238/4885MAPK1 3538/4885 |
| US-20200385341-A1 | CATHEPSIN INHIBITORS | CTSK, CTSZ, CTSF | LMNA 2792/4885ALDH1A1 3238/4885MAPK1 3538/4885 |
| US-11174224-B2 | Cathepsin inhibitors | CTSK, CTSZ, CTSF | LMNA 2792/4885ALDH1A1 3238/4885MAPK1 3538/4885 |
| US-20220227705-A1 | CATHEPSIN INHIBITORS | CTSK, CTSZ, CTSF | LMNA 2792/4885ALDH1A1 3238/4885MAPK1 3538/4885 |
| US-20240182409-A1 | CATHEPSIN INHIBITORS | CTSK, CTSZ, CTSF | LMNA 2792/4885ALDH1A1 3238/4885MAPK1 3538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.