Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328557 | 0.91 | ADRB2 (0.43) | ADRB2ALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL6850180 | 0.91 | MMP9 (0.40) | ALDH1A1GAA | |
| SCHEMBL328556 | 0.90 | MMP3 (0.40) | KMT2AMEN1MAPTPSEN1PSEN2 | |
| SCHEMBL10066483 | 0.88 | MMP3 (0.41) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL328544 | 0.83 | DAGLA (0.35) | ALDH1A1KMT2AHPGDPOLBCYP2C19 | |
| SCHEMBL328560 | 0.82 | MMP3 (0.44) | — | |
| SCHEMBL6863812 | 0.81 | MMP3 (0.52) | — | |
| SCHEMBL328555 | 0.79 | MMP3 (0.53) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL6852266 | 0.79 | HRH3 (0.36) | ADRB2KMT2A | |
| SCHEMBL328414 | 0.79 | DAGLA (0.37) | ALDH1A1KMT2AHPGDPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |