Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 3/20 | 0.52 |
| ▸ | AHCY | P23526 | 6/20 | 0.39 |
| ▸ | MMP1 | P03956 | 6/20 | 0.37 |
| ▸ | MMP13 | P45452 | 5/20 | 0.37 |
| ▸ | BMP1 | P13497 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 5/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.37 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | MMP16 | P51512 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328560 | 0.94 | MMP3 (0.44) | MMP3MMP1MMP13BMP1MMP8 | |
| SCHEMBL328555 | 0.92 | MMP3 (0.53) | MMP3MMP1MMP13BMP1MMP8 | |
| SCHEMBL328556 | 0.91 | MMP3 (0.40) | MMP3AHCYMMP9MMP2 | |
| SCHEMBL328557 | 0.90 | ADRB2 (0.43) | MMP3AHCYMMP1MMP13BMP1 | |
| SCHEMBL328413 | 0.86 | MMP3 (0.51) | MMP3AHCYMMP1MMP13BMP1 | |
| SCHEMBL10067178 | 0.86 | MMP3 (0.50) | MMP3AHCYKDM4E | |
| SCHEMBL10067173 | 0.85 | MMP3 (0.49) | MMP3AHCYMMP1MMP13BMP1 | |
| SCHEMBL10067177 | 0.85 | MMP3 (0.44) | MMP3MMP1MMP13BMP1MMP8 | |
| SCHEMBL6850180 | 0.84 | MMP9 (0.40) | MMP3MMP1MMP13MMP9ADAM17 | |
| SCHEMBL328649 | 0.83 | MMP1 (0.44) | MMP3MMP1MMP13BMP1MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041545-A1 | METHODS OF TREATING ANEURYSMAL DILATATION, BLOOD VESSEL WALL WEAKNESS AND SPECIFICALLY ABDOMINAL AORTIC AND THORACIC ANEURYSM USING MATRIX METALLOPROTEASE-2 INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2011-04-07 | — | — | WO | disclosed |