Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328410 | 0.91 | MEP1B (0.42) | SCN9ACACNA1HCACNA1BMMP2BMP1 | |
| SCHEMBL6850876 | 0.81 | MMP1 (0.46) | LMNAALDH1A1MMP2BMP1 | |
| SCHEMBL6850891 | 0.81 | ALDH1A1 (0.43) | CACNA1HCACNA1BLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL328415 | 0.81 | RXFP1 (0.42) | SCN9ALMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL328402 | 0.80 | MEP1B (0.44) | ALDH1A1MMP2BMP1 | |
| SCHEMBL328417 | 0.71 | MEN1 (0.43) | LMNASMN1; SMN2POLBALDH1A1MEN1 | |
| SCHEMBL10067174 | 0.71 | MMP1 (0.54) | LMNAALDH1A1MMP2BMP1 | |
| SCHEMBL328416 | 0.71 | SMN1; SMN2 (0.35) | CACNA1HCACNA1BLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL328404 | 0.70 | BMP1 (0.43) | ALDH1A1MMP2BMP1 | |
| SCHEMBL6850926 | 0.70 | POLB (0.46) | LMNASMN1; SMN2POLBALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |