Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 5/20 | 0.50 |
| ▸ | TACR2 | P21452 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.45 |
| ▸ | AKT1 | P31749 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6853374 | 0.84 | TACR3 (0.50) | TACR3TACR2KDM4EALDH1A1KMT2A | |
| SCHEMBL5945358 | 0.81 | SLC2A1 (0.46) | TACR3TACR2AKT1OPRM1 | |
| SCHEMBL6853531 | 0.80 | DRD2 (0.50) | KDM4EALDH1A1KMT2AAKT1 | |
| SCHEMBL6854970 | 0.77 | KMT2A (0.50) | KDM4EALDH1A1KMT2AAKT1KCNH2 | |
| SCHEMBL6848917 | 0.77 | TACR3 (0.70) | TACR3TACR2TRPV4KCNH2OPRM1 | |
| SCHEMBL6851740 | 0.76 | AKT1 (0.48) | KDM4EALDH1A1AKT1KCNH2HSD17B10 | |
| SCHEMBL6853013 | 0.76 | HRH3 (0.48) | POLBKDM4EALDH1A1KMT2ACYP2C9 | |
| SCHEMBL5442168 | 0.75 | PDE10A (0.43) | POLBKDM4EALDH1A1KMT2AAKT1 | |
| SCHEMBL6848935 | 0.73 | SLC2A1 (0.44) | TACR3TACR2KDM4EALDH1A1KCNH2 | |
| SCHEMBL6853077 | 0.73 | HTR2B (0.49) | KDM4EALDH1A1KMT2ACYP2C9CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | disclosed |