Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6853077 | 0.90 | HTR2B (0.49) | KMT2ASIGMAR1ALDH1A1DRD2DRD4 | |
| SCHEMBL6853013 | 0.88 | HRH3 (0.48) | KMT2ANPC1RAB9ACYP2D6ALDH1A1 | |
| SCHEMBL6848678 | 0.84 | TACR2 (0.53) | LMNAKCNH2FAAHPDE10A | |
| SCHEMBL6848935 | 0.84 | SLC2A1 (0.44) | NCF1CYP2D6KCNH2ALDH1A1FAAH | |
| SCHEMBL5908682 | 0.84 | FAAH (0.42) | KMT2ANPC1RAB9AMEN1LMNA | |
| SCHEMBL5442168 | 0.84 | PDE10A (0.43) | KMT2ANPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL6853643 | 0.83 | TSHR (0.55) | KMT2ANPC1RAB9AMEN1LMNA | |
| SCHEMBL6853186 | 0.83 | LDHA (0.49) | KMT2AMEN1KCNH2FAAHKDM4E | |
| SCHEMBL5945358 | 0.83 | SLC2A1 (0.46) | NPC1RAB9AFAAHAKT1PDE10A | |
| SCHEMBL6851670 | 0.82 | PDE10A (0.43) | NCF1ALDH1A1MAPTFAAHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | disclosed |