Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | TACR2 | P21452 | 7/20 | 0.41 |
| ▸ | TACR3 | P29371 | 7/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851670 | 0.88 | PDE10A (0.43) | PDE10AFAAHTACR2TACR3PIK3CD | |
| SCHEMBL6848678 | 0.88 | TACR2 (0.53) | SLC2A1PDE10AFAAHTACR2TACR3 | |
| SCHEMBL6853013 | 0.86 | HRH3 (0.48) | SLC2A1PDE10AFAAHPIK3CDCYP2D6 | |
| SCHEMBL6854970 | 0.84 | KMT2A (0.50) | PDE10AFAAHCYP2D6KCNH2NCF1 | |
| SCHEMBL6853072 | 0.81 | ADORA2A (0.53) | SLC2A1FAAHTACR3NCF1ALDH1A1 | |
| SCHEMBL5908682 | 0.80 | FAAH (0.42) | PDE10AFAAHPIK3CDBACE1PIK3CG | |
| SCHEMBL6853077 | 0.80 | HTR2B (0.49) | FAAHKDM4EALDH1A1HTT | |
| SCHEMBL5442168 | 0.80 | PDE10A (0.43) | PDE10AFAAHPIK3CDPIK3CGKDM4E | |
| SCHEMBL6853643 | 0.79 | TSHR (0.55) | KDM4EALDH1A1HTT | |
| SCHEMBL6853186 | 0.79 | LDHA (0.49) | PDE10AFAAHTACR3PIK3CDKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | disclosed |