Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6854970 | 0.88 | KMT2A (0.50) | PDE10AKMT2AFAAHKDM4EALDH1A1 | |
| SCHEMBL6851670 | 0.86 | PDE10A (0.43) | PDE10AFAAHPIK3CDBACE1KDM4E | |
| SCHEMBL6848935 | 0.86 | SLC2A1 (0.44) | PDE10AFAAHPIK3CDBACE1SLC2A1 | |
| SCHEMBL6848678 | 0.86 | TACR2 (0.53) | HRH3PDE10AFAAHPIK3CDBACE1 | |
| SCHEMBL6853072 | 0.84 | ADORA2A (0.53) | HRH3KMT2AFAAHSLC2A1ALDH1A1 | |
| SCHEMBL5908682 | 0.83 | FAAH (0.42) | PDE10AKMT2AFAAHPIK3CDBACE1 | |
| SCHEMBL6853077 | 0.83 | HTR2B (0.49) | KMT2AFAAHKDM4EALDH1A1CYP2C9 | |
| SCHEMBL5442168 | 0.83 | PDE10A (0.43) | PDE10AKMT2AFAAHPIK3CDKDM4E | |
| SCHEMBL6853643 | 0.82 | TSHR (0.55) | KMT2AKDM4EALDH1A1NPC1POLB | |
| SCHEMBL6853186 | 0.82 | LDHA (0.49) | PDE10AKMT2AFAAHPIK3CDBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | disclosed |