Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 7/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | TACR2 | P21452 | 6/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851652 | 0.84 | TACR3 (0.50) | TACR3KCNH2TACR2OPRM1ALDH1A1 | |
| SCHEMBL6854970 | 0.81 | KMT2A (0.50) | KCNH2DRD4DRD3ALDH1A1KDM4E | |
| SCHEMBL5945358 | 0.81 | SLC2A1 (0.46) | TACR3TACR2OPRM1 | |
| SCHEMBL6853013 | 0.80 | HRH3 (0.48) | ALDH1A1KDM4EHRH3KMT2A | |
| SCHEMBL6853531 | 0.80 | DRD2 (0.50) | DRD4DRD3ALDH1A1KDM4EMEN1 | |
| SCHEMBL6848935 | 0.77 | SLC2A1 (0.44) | TACR3KCNH2TACR2OPRM1ALDH1A1 | |
| SCHEMBL6853077 | 0.77 | HTR2B (0.49) | DRD4DRD3ALDH1A1KDM4ESIGMAR1 | |
| SCHEMBL5908682 | 0.77 | FAAH (0.42) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6848678 | 0.77 | TACR2 (0.53) | TACR3KCNH2TACR2OPRM1HRH3 | |
| SCHEMBL5442168 | 0.77 | PDE10A (0.43) | ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | disclosed |